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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: reporting in brief but relevant information is available

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Principles of method if other than guideline:
Single oral application by gavage of 5000 mg/kg bw dissolved in lutrol to 10 male Wistar rats; observation time: 14 days
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N'-dimethyldiphenylthiuram disulphide
EC Number:
234-196-6
EC Name:
N,N'-dimethyldiphenylthiuram disulphide
Cas Number:
10591-84-1
Molecular formula:
C16H16N2S4
IUPAC Name:
N-methyl-N-phenyl{[methyl(phenyl)carbamothioyl]disulfanyl}carbothioamide
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
purity 98.1 %

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 160-180 g
- Housing: 5 /cage

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: lutrol
Details on oral exposure:
single oral application by gavage
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
Single oral application by gavage of 5000 mg/kg bw dissolved in lutrol to 10 male Wistar rats; observation time: 14 days LD 50 calcuation according to Fink and Hund Arneim.-forsch. 15, 624 (1965)
Statistics:
no further data

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Remarks on result:
other: no mortality no clinical findings
Mortality:
0/10
Clinical signs:
other: no clinical findings
Gross pathology:
not examined
Other findings:
no further data

Applicant's summary and conclusion

Executive summary:

Single oral application by gavage of 5000 mg/kg bw to 10 male rats caused no death and no clinical findings were observed during the 14 day-observation period. Thus, the LD50 was considered to be >5000 mg/kg bw (Loeser 1976)