Registration Dossier
Registration Dossier
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EC number: 234-196-6 | CAS number: 10591-84-1
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: reporting in brief
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxizität und Wirkung einiger Thiuramdisulfid-verbindungen auf den alkoholstoffwechsel
- Author:
- Kirchheim D
- Year:
- 1 951
- Bibliographic source:
- Arch exp Path Pharmacol 214, 59-66
Materials and methods
- Principles of method if other than guideline:
- single application of testsubstance by gavage 24 hours after single oral treatment with 10% ethanol solution. Determination ofacetaldehyd concentration in blood
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- acute toxicity: oral
Test material
- Reference substance name:
- N,N'-dimethyldiphenylthiuram disulphide
- EC Number:
- 234-196-6
- EC Name:
- N,N'-dimethyldiphenylthiuram disulphide
- Cas Number:
- 10591-84-1
- Molecular formula:
- C16H16N2S4
- IUPAC Name:
- N-methyl-N-phenyl{[methyl(phenyl)carbamothioyl]disulfanyl}carbothioamide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- body weight at study initiation:2-3 kg
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on exposure:
- it is suggested that the testsubstance prevents the metabolisation of ethanol and therefore increase in acetaldehyde concentration can be detected.
Therefore rabbits received 30 ml 10 % ethanol solution 24 hours before receiving 500, 150 or 50 mg/kg bw of the testsubstance.
12-18 hours later acetaldehyde concentration in the blood was measured and compared with blood acetaldehyde concentration measured before and after ethanol application. - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- no data
- Duration of treatment / exposure:
- snigle application
- Frequency of treatment:
- single application
- Post exposure period:
- 12-18 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 50, 150, 500 mg/kg bw
Basis:
- No. of animals per sex per dose:
- 1
- Control animals:
- other: measurement before the start of the experiment
- Details on study design:
- no further data
Examinations
- Examinations:
- measurement of acetaldehyyde ub blood
- Positive control:
- no data
Results and discussion
- Details on results:
- Vulkacit I has no effect on acetaldehyde concentration in blood after ingestion of alcohol
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
