(8α,9R,8'''α,9'''R)-1,1'-[(2,3,5,6-tetrafluoro-1,4-phenylene)bis(methylene)]bis(6'-methoxycinchonan-1-ium-9-ol) dibromide

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)

Version / remarks:

2015

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Key result

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

The test substance melted, charred, ignited and fumed on application of the ignition source, but the flames self-extinguished rapidly on its removal. It did not propagate combustion and the burning time over 200 mm could not be determined.

Interpretation of results:

not classified based on GHS criteria

Conclusions:

The substance did not propagate combustion and is not considered as a flammable solid.

Executive summary:

The flammability of the substance was tested under GLP to UN Test N.1. The test substance was formed into an unbroken train of material, approximately 250 mm long, on a non-combustible, impervious, low heat-conducting base plate. Tests were carried out to investigate the burning characteristics of the sample using an air-rich Bunsen burner flame as the ignition source. A preliminary screening test was conducted to determine whether or not the sample ignites and propagates combustion over 200 mm within 2 minutes, either by burning with a flame or by smouldering.

The test substance melted, charred, ignited and fumed on application of the ignition source, but the flames self-extinguished rapidly on its removal. It did not propagate combustion and the burning time over 200 mm could not be determined.

Since the test substance did not propagate combustion, a full test was not required.

Reference 2

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)

Version / remarks:

2015

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Key result

Test procedure:

other: 50 mm at 165 °C

Remarks:

Due to limited sample availability, a 50 mm container was used and temperature was modified such that the test point complied with the same size-temperature relationship as the self-ignition temperature of charcoal.

Max. temp. reached:

351.2

Induction time (h):

3.5

Result:

positive outcome (effect observed)

Remarks on result:

other:

Remarks:

Test temperature of 165 °C for 50 mm cube corresponds to temperature of 140 °C for 100 mm cube

Key result

Test procedure:

25 mm sample cube at 140°C

Max. temp. reached:

141.5

Induction time (h):

15

Result:

negative outcome (no effect observed)

Key result

Test procedure:

other: 50 mm cube at 142 °C

Max. temp. reached:

145.9

Induction time (h):

16

Result:

negative outcome (no effect observed)

Remarks on result:

other:

Remarks:

Test temperature of 142 °C for 50 mm cube corresponds to 120 °C for 100 mm cube

Interpretation of results:

Category 2 (flammable solids) based on GHS criteria

Conclusions:

Based on the test results the substance does not require classification if packaged in sizes of not more than 3 cubic metres, but is classified as a self-heating solid, category 2 and assigned to Division 4.2, Packaging Group III for transport, if packed in sizes greater than 3 cubic metres.

Executive summary:

As the heat of decomposition was determined to exceed 300 J/g in the differential scanning calorimetry study, the self-heating properties of the substance were tested under GLP to UN Test N.4, by using a modified version of the Bowes-Cameron cage test for carbon. The volumes, temperature and criteria for classification were based on the self-ignition temperature of charcoal, which are 50 ° for volumes of 27 m3 and 140 °C for volumes of 1 litre. During each test, a cubic open-topped basket made of 50 μm stainless steel wire mesh was filld to the brim with the test substance. Teh container was then housed within a slightly larger cubic container made of 600 μm stainless steel mesh and the combination was suspended centrally within a hot air circulation oven. The container and cover were housed within a second stainless steel cage having a mesh size of ca. 600 μm to avoid the effects of air circulation. The substance was then held at a specified temperature for a period of 24 hours and the sample temperature monitored for signs of self-heating.

Due to limited sample availability, a 50 mm container was used and the test temperatures were modified such that the test point complied with the same size-temperature relationship as the self-ignition temperatures of charcoal, i.e. the corresponding temperatures for the 50 mm cube were 165, 142 and 120 °C instead of 140, 120 and 100 °C. In the initial test using a 50 mm cube at 165 °C, the substance showed a positive results expressed as a significant exothermic activity with the sample reaching a maximum temperature of 351.2 °C after 3.5 hours. This triggered a test with a 25 mm container at 140 °C, which produced a negative result as the sample reached a maximum temperature of 141.5 °C after ca. 15 hours. A final test was then conducted with the 50 mm cube at 142 °C, in which the substance showed minor exothermic activity with the sample reaching a maximum temperature of 145.9 °C after 15 to 16 hours. This result was considered to be negative, and no further testing was necessary. Based on the test results, the substance is exempt from classification as a self-heating substance if packaged in sizes of not more than 3 cubic metres, but meets the criteria for classification as a self-heating substance of Cat. 2 requiring Division 4.2 Packaging Group III for transport if packaged in sizes greater than 3 cubic metres.

Description of key information

Not classified as a flammable solid (GLP, UN Test N.1)

Classified as a self-heating substance Cat. 2, Division 4.2 Packaging Group III, if packed in sizes greater than 3 cubic metres (GLP, UN Test N.4)