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EC number: 419-560-6 | CAS number: 4369-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7th April 1994 - 28th July 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 419-560-6
- EC Name:
- -
- Cas Number:
- 4369-14-6
- Molecular formula:
- C9H18O5Si
- IUPAC Name:
- 3-(trimethoxysilyl)propyl prop-2-enoate
1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Japan, Inc.
- Females nulliparous and non-pregnant: Yes
- Age at study initiation: 5 weeks old
- Weight at study initiation: Males 104-113.7 g; females: 93.9 - 101.9 g
- Fasting period before study: Yes, overnight
- Housing: Individually
- Diet (e.g. ad libitum): MF pelleted diet, ad libitum
- Water (e.g. ad libitum): Municipal water, ad libitum
- Acclimation period: Yes, but duration not specified
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 +/- 2
- Humidity (%): 55 +/- 10
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE:
- Concentration in vehicle: 0, 10 and 20 w/v % in olive oil
- Amount of vehicle (if gavage): 10 mL/kg
- Justification for choice of vehicle: Not specified
DOSAGE PREPARATION (if unusual): The test substance was weighed and dissolved in olive oil. The dose formulations were prepared daily before dosing. Stability of the test substance in dose formulations were confirmed for 3 days before dosing. Test concentrations were confirmed. - Doses:
- 0, 1000 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5M, 5F
- Control animals:
- yes
- Remarks:
- vehicle (olive oil) control
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations for general condition were carried out continuously up to 6 hours post-dosing, and once a day until 14 days post-dosing. Body weights were recorded at days 1, 3, 7, 10 and 14.
- Necropsy of survivors performed: Yes
- Other examinations performed: In each animal surface, orifices, organs in skull, thoracic cavity and abdominal cavity were examined macroscopically. - Statistics:
- Mean values and standard deviations for body weights in each group were calculated.
Results and discussion
- Preliminary study:
- Doses: 0, 20, 100, 500, and 2000 mg/kg bw
Mortality data: No animals died at any of the tested dose levels.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No males died during the study.
One female at 2000 mg/kg bw died 1 day after dosing. Decreased spontaneous locomotion, respiratory rate, ptosis and salivation, mucous stool, and soft stool were observed from 30 minutes after dosing in this female. - Clinical signs:
- other: Males: Decreased spontaneous locomotion, respiratory rate, ptosis and salivation were observed from 15 minutes after dosing at 2000 and 1000 mg/kg bw. These effects resolved by day 1 post-dosing. Mucous stool was seen in males at 0, 1000, and 2000 mg/kg b
- Gross pathology:
- Dead female at 2000 mg/kg bw: Reddish spots in the mucosa of the glandular stomach were observed.
Surviving females: No abnormalities were seen at any dose.
Males (all survived): Adhesion to the diaphragm and liver (1/5) in the forestomach was seen at 2000 mg/kg bw, with no abnormalities noted at 1000 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the acute oral toxicity study with 3-(trimethoxysilyl)propyl acrylate in olive oil, conducted according to the now-deleted OECD Test Guideline 401 and in compliance with GLP, the LD50 value was >=2000 mg/kg bw in male and female rats.
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