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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 22 March 2002 to 18 October 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
not specified
Key result
Type:
Pow
Partition coefficient:
< 0.002
Remarks on result:
other: Room temperature - The value pH is not provided
Key result
Type:
log Pow
Partition coefficient:
< -2.7
Remarks on result:
other: Room temperature - The value pH is not provided
Details on results:
The preliminary test indicated that the test item was weakly soluble in n-octanol (< 1 g/L).The solubility in water of SODIUM CHLORITE was previously determined to be > 500 g/L(CIT/Study No. 22374 PSE).This estimate indicates a negative log Pow.The shake-flask method enables partition coefficient to be determined in the log Pow rangebetween -2 and 4, thus the shake-flask method was not applicable.Consequently, the test was considered to be complete.
Conclusions:
The result was as follows (Estimation based on the individual solubilities of the test item in n-octanol and water)::Pow < 1/500Pow < 0.002 and log Pow < -2.7 at room temperature.
Executive summary:

The aim of this study was the determination of the partition coefficient of the test material.

The test procedure used was the EU Method A8 and the OECD test guideline 107.

The method for analysis was the shake flask method.

The result was as follows ( Estimation based on the individual solubilities of the test item in n-octanol and water):

Pow< 1/500

Pow <0.002 and log Pow< -2.7 at room temperature

Description of key information

Key study according to EU Method A8 and the OECD test guideline 107.

The result was as follows (Estimation based on the individual solubilities of the test item in n-octanol and water):

Pow< 1/500

Pow <0.002 and log Pow< -2.7 at room temperature.

Key value for chemical safety assessment

Log Kow (Log Pow):
-2.7
at the temperature of:
25 °C

Additional information

Key study according to EU Method A8 and the OECD test guideline 107.

The result was as follows (Estimation based on the individual solubilities of the test item in n-octanol and water):

Pow< 1/500

Pow <0.002 and log Pow< -2.7 at room temperature