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Ecotoxicological information

Toxicity to microorganisms

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Endpoint:
activated sludge respiration inhibition testing
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
2006
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read across to Pigment Red 3 and Pigment Orange 5 – these are other substances in the Monoazo Red consortium which is a structural analogue
Justification for type of information:
Category of Monoazo Red Pigments (C.I. PIGMENT RED 3, C.I. PIGMENT RED 4, C.I. PIGMENT ORANGE 5)
1. HYPOTHESIS FOR THE CATEGORY APPROACH
A very similar chemical structure is the basis for similar physical-chemical properties as very low solubility in water (but also in organic solvents and lipophilic matrices) and non-degradability which lead to inert behaviour and negligible bioavailability. See attached PR4_CSR.doc in Section 13 (1.1.1. Category Definition and its members - Category Hypothesis).
2. CATEGORY APPROACH JUSTIFICATION
Monoazo Red Pigments do not exert toxic effects to aquatic, terrestrial and sediment organisms as well as bacteria. See attached PR4_CSR.doc in Section 13 (1.1.1. Category Definition and its members - Category Justification).
Qualifier:
according to
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
Deviations:
no
GLP compliance:
yes (incl. certificate)
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
activated sludge, domestic
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
3 h
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Validity criteria fulfilled:
yes
Conclusions:
The test item is not toxic at concentrations ≤ 1000 mg/L to activated sludge of a municipal sewage treatment plant.
Endpoint:
activated sludge respiration inhibition testing
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
2007
Reliability:
1 (reliable without restriction)
Justification for type of information:
Category of Monoazo Red Pigments (C.I. PIGMENT RED 3, C.I. PIGMENT RED 4, C.I. PIGMENT ORANGE 5)
1. HYPOTHESIS FOR THE CATEGORY APPROACH
A very similar chemical structure is the basis for similar physical-chemical properties as very low solubility in water (but also in organic solvents and lipophilic matrices) and non-degradability which lead to inert behaviour and negligible bioavailability. See attached PR4_CSR.doc in Section 13 (1.1.1. Category Definition and its members - Category Hypothesis).
2. CATEGORY APPROACH JUSTIFICATION
Monoazo Red Pigments do not exert toxic effects to aquatic, terrestrial and sediment organisms as well as bacteria. See attached PR4_CSR.doc in Section 13 (1.1.1. Category Definition and its members - Category Justification).
Qualifier:
according to
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
GLP compliance:
yes (incl. certificate)
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
activated sludge, domestic
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
3 h
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Validity criteria fulfilled:
yes
Conclusions:
The test item is not toxic at concentrations <1000 mg/L to activated sludge from a municipal treatment plant

Description of key information

Neither C.I. Pigment Red 3 or C.I. Pigment Orange 5 are toxic at concentrations ≤ 1000 mg/L to activated sludge of a municipal sewage treatment plant.

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L

Additional information