Registration Dossier
Registration Dossier
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EC number: 938-094-9 | CAS number: -
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- Haemorrhages due to defective blood coagulation do not occur in mice and guinea-pigs fed butylated hydroxytoluene, but nephrotoxicity is found in mice.
- Author:
- Takahashi
- Year:
- 1 992
- Bibliographic source:
- Food Chem Toxicol. 1992 Feb; 30(2): 89-97
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Subacute Dietary Toxicity Study
- Principles of method if other than guideline:
- Subacute Dietary Toxicity Study
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,6-di-tert-butyl-p-cresol
- EC Number:
- 204-881-4
- EC Name:
- 2,6-di-tert-butyl-p-cresol
- Cas Number:
- 128-37-0
- Molecular formula:
- C15H24O
- IUPAC Name:
- Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-
- Details on test material:
- data for components
Constituent 1
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Study observed:
dose-related toxic nephrosis was found in mice given 1.35-5.0% BHT in the diet.
The nephrotoxic ED50 (1 month) was 2300 mg/kg body weight/day.
Authors concluded that an extremely large dose of BHT can cause renal toxicity in mice.
LOAEL =1570 mg/kg bw/day (renal toxicity effects)
Applicant's summary and conclusion
- Conclusions:
- Data on component: LOAEL =1570 mg/kg bw/day (renal toxicity effects)
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