Registration Dossier
Registration Dossier
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EC number: 938-094-9 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- Butylated Hydroxytoluene
- Author:
- World Health Organization/ International Programme on Chemical Safety
- Year:
- 1 964
- Bibliographic source:
- WHO/Food Additives Report 38A (1964)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Peer reviewed scientific evaluation report
- Principles of method if other than guideline:
- Peer reviewed scientific evaluation report
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,6-di-tert-butyl-p-cresol
- EC Number:
- 204-881-4
- EC Name:
- 2,6-di-tert-butyl-p-cresol
- Cas Number:
- 128-37-0
- Molecular formula:
- C15H24O
- IUPAC Name:
- Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-
- Details on test material:
- Substance component
Constituent 1
Results and discussion
Any other information on results incl. tables
Absorbtion:
BHT was readily absorbed.
Distribution:
High doses of BHT administered to rats showed some deposition in adipose tissue.
Metabolites:
Metabolites observed in studies in rabbits after single or repeated doses of BHT included ester glucuronide and ether glucuronide
Applicant's summary and conclusion
- Conclusions:
- ADME data summarised in a peer review evaluation report (component data)
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