Registration Dossier
Registration Dossier
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EC number: 938-094-9 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
For detailed data on DNEL/DMEL values assigned for the substance, please, refer Chemical Safety Assessment Report (CSR)
Health effects ofReaction mass of 2,6-di-tert-butyl-p-cresol, 4,6-di-tert-butyl-o-cresol and 2,6-di-tert-butylphenol componentshave been studied comprehensively and reviewed by the National Toxicology Program (NTP, 1979), the World Health Organisation (WHO, 1987), the International Agency for Research on Cancer (IARC, 1986, 1987), the Joint FAO/WHO Expert Committee on Food Additives (JECFA, 1996), the OECD High Production Volume chemicals evaluation programme (OECD, SIDS, 2005), the European Food Safety Authority (EFSA) Panel on Food Additives and Nutrient Sources added to Food (EFSA, 2012). Because these reports have undergone several levels of technical review, it is assumed for the purpose of the present CSR that any referenced toxicity data cited in them are also reliable.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
For detailed data on DNEL/DMEL values assigned for the substance, please, refer Chemical Safety Assessment Report (CSR).
Health effects ofReaction mass of 2,6-di-tert-butyl-p-cresol, 4,6-di-tert-butyl-o-cresol and 2,6-di-tert-butylphenol componentshave been studied comprehensively and reviewed by the National Toxicology Program (NTP, 1979), the World Health Organisation (WHO, 1987), the International Agency for Research on Cancer (IARC, 1986, 1987), the Joint FAO/WHO Expert Committee on Food Additives (JECFA, 1996), the OECD High Production Volume chemicals evaluation programme (OECD, SIDS, 2005), the European Food Safety Authority (EFSA) Panel on Food Additives and Nutrient Sources added to Food (EFSA, 2012). Because these reports have undergone several levels of technical review, it is assumed for the purpose of the present CSR that any referenced toxicity data cited in them are also reliable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
