Registration Dossier
Registration Dossier
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EC number: 203-744-6 | CAS number: 110-18-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A theoretical assessment of the toxicokinetic properties of TMEDA is provided.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Absorption
TMEDA is of low molecular weight (Mw 116) and is miscible with water; these properties will favour oral absorption. TMEDA is also predicted to be orally bioavailable according to Lipinski's rules (OECD Toolbox: OASIS). The results of the OECD 422 screening study with TMEDA indicate systemic toxicity consistent with oral bioavailability. In the absence of data on dermal and inhalation absorption, default assumptions are made. The physicochemical properties of TMEDA indicate that dermal absorption is likely; it is also noted that TMEDA is corrosive to skin and may therefore affect the integrity of the skin as a barrier to absorption.
Distribution
The results of the OECD 422 screening study indicate distribution to the liver (increased AST activity) and also post-hepatic systemic distribution (haematological effects).
Metabolism
OECD Toolbox metabolism simulators indicate that TMEDA is likely to be metabolised in the liver through a combination of N-demethylation and oxidative reactions to produce small water-soluble metabolites. A total of 8 metabolites are predicted, some of which may be incorporated into normal metabolism.
Excretion
TMEDA is a small, highly water-soluble molecule and is therefore likely to be subject to renal excretion. The predicted metabolites of TMEDA are also small and water soluble and similarly likely to be subject to renal excretion. Biliary excretion is not predicted.
Bioaccumulation
Based on its physicochemical properties and predicted metabolism, bioaccumulation is considered to be unlikely. However it is noted that some of the predicted metabolites of TMEDA may be incorporated into normal metabolism.
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