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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
in vitro
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010-07-02 to 2010-07-03
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP and OECD Guideline compliant study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Caesium carbonate
EC Number:
208-591-9
EC Name:
Caesium carbonate
Cas Number:
534-17-8
Molecular formula:
CH2O3.2Cs
IUPAC Name:
Cesium carbonate
Test material form:
solid: crystalline

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: formazan production in comparison to the negative control
Basis:
mean
Remarks:
test item
Time point:
other: 3 min
Score:
102.6
Reversibility:
other: not applicable in in vitro studies
Irritation parameter:
other: formazan production in comparison to the negative control
Basis:
mean
Remarks:
test item
Time point:
other: 1 h
Score:
47.4
Reversibility:
other: not applicable in in vitro studies
Irritation parameter:
other: formazan production in comparison to the negative control
Basis:
mean
Remarks:
positive control
Time point:
other: 3 min
Score:
25.5
Reversibility:
other: not applicable in in vitro studies
Irritation parameter:
other: formazan production in comparison to the negative control
Basis:
mean
Remarks:
positive control
Time point:
other: 1 h
Score:
20.3
Reversibility:
other: not applicable in in vitro studies

Applicant's summary and conclusion

Interpretation of results:
other: not corrosive
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
According to OECD Guideline 431 study the test item is considered to be not corrosive.
Executive summary:

The test item is considered to be not corrosive. After three minutes treatment, the relative absorbance values were decreased to 102.6 %. This value is well above the threshold for corrosivity (50 %). After one hour treatment relative absorbance values were reduced to 47.4 %. This value is well above the threshold for corrosivity (15 %). The values of the negative control were well above the required acceptability criterion of mean OD > 0.8 for both treatment interval thus showing the quality of the tissues. The value of the positive control induced a decrease in the relative absorbance as compared to the negative control to 25.5 % for the three minutes treatment interval and 20.3 % for the one hour treatment interval thus ensuring the validity of the test system. Although the value of the one-hour-experiment was 20.3 % and therefore higher than the threshold for corrosivity, this is considered as not relevant, as a clear corrosive effect was determined and values above 15 % have been measured for the positive control before: Values for the positive control were within the range of historical data of the test facility.