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EC number: 203-464-4 | CAS number: 107-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Propiononitrile
- EC Number:
- 203-464-4
- EC Name:
- Propiononitrile
- Cas Number:
- 107-12-0
- Molecular formula:
- C3H5N
- IUPAC Name:
- propanenitrile
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Average temperature inside the chamber between 24-25 degree Celsius. Average relative humidity inside chamber was 70%.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- The animals were placed in cages and the cages suspended in the middle of a 210-litre drum-like chamber. The chamber was equipped with the circulating fan (6-inch blade) and a glass window. The sample was introduced into the chamber through a special port by a means of a glass syringe fitted with a g 27 needle. During the delivery of a sample the sample was spread towards the chamber to facilitate evaporation. The circulating fan was operated at maximum speed during the introduction of a sample and for an additional two minutes. No supplementary air was introduced in as much as the volume of the air in the chamber was ample for the requirement of oxygen for the animals.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Remarks on duration:
- Exposure to the test substance lasted 4 hours, observations were made for 14 days.
- Concentrations:
- 1.58, 2.51, 3.98, 6.31, 10.0, 15.8 mg/L.
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 3.3 mg/L air
- Based on:
- test mat.
- 95% CL:
- >= 2.6 - <= 4.3
- Exp. duration:
- 4 h
- Mortality:
- Five out of five males died following exposure to 2.51 mg/L of the test substance (1 died in <4 hours and 4 in 1 day). Five out of five males died following exposure to 2.51 mg/L (2 died in <4 hours, 1 in one day, 1 in 2 days, and 1 in 13 days). Five out of five males died in <4 hours of exposure to 6.31, 10 and 15.8 mg/L of the test substance. Three out of five females died (1 < 4 hours; 2 in 1 day) following exposure to 6.31 mg/L of the test substance. Five out of five females died following exposure to 10 mg/L (in 1 day) and 15.8 mg/L (in <4 hours).
- Clinical signs:
- other: Salivation, lethargy, increased weakness, tremors and convulsions, collapse and death.
- Gross pathology:
- Decedents had haemorrhagic lungs, liver discoloration (mottled in some) and acute gastrointestinal inflammation.
In survivors (14 days) viscera appeared normal.
Any other information on results incl. tables
Inhalation of propionitrile vapors by male and female rats.
Concentration of the substance (mg/L) | Male mortality (number/total) | Female mortality (number/total) | Total mortality (number/total) |
1.58 | 0/5 | 0/5 | 0/10 |
2.51 | 5/5 (1<4 hours; 4 in 1 day) | 0/5 | 5/10 |
3.98 | 5/5* | 0/5 | 5/10 |
6.31 | 5/5 < 4 hours | 3/5 (1 < 4 hours; 2 in 1 day) | 8/10 |
10.0 | 5/5 < 4 hours | 5/5 < 1 day | 10/10 |
15.8 | 5/5 < 4 hours | 5/5 < 4 hours | 10/10 |
* 2 dead in <4 hours, 1 in one day, 1 in 2 days, and 1 in 13 days.
LC50: 3.3 mg/L; 95% confidence limits: 2.6 -4.3 mg/L; Slope: 4.1.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The LC50 for males and females was considered to be 3.3 mg/L.
- Executive summary:
The substance was used in an in vivo acute inhalation toxicity study using male and female rats (n=5/sex). The animals were exposed to 1.58, 2.51, 3.98, 6.31, 10.0 and 15.8 mg/L of the test substance in a vapour form. The sample was introduced into the chamber through a special port by a means of a glass syringe. Five out of five males died following exposure to 2.51 mg/L of the test substance (1 died in <4 hours and 4 in 1 day). Three out of five females died (1 < 4 hours; 2 in 1 day) following exposure to 6.31 mg/L of the test substance. The LC50 for males and females was considered to be 3.3 mg/L.
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