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EC number: 203-464-4 | CAS number: 107-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2nd July 1979- 31st July 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 2079
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Propiononitrile
- EC Number:
- 203-464-4
- EC Name:
- Propiononitrile
- Cas Number:
- 107-12-0
- Molecular formula:
- C3H5N
- IUPAC Name:
- propanenitrile
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male rats used in the study with average weight/dose ranging 230-245 g; Female rats used in the study with average weight/dose ranging 235-245 g.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Administered to male: 50.1, 63.1, 79.4, 100, 126, 158 mg/kg body weight;
Administered to female: 158, 200, 251, 316 mg/kg body weight. - No. of animals per sex per dose:
- 5 males/dose; and 5 females/dose.
- Control animals:
- not specified
- Statistics:
- 95% confidence limits stated
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 75 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 58 - 98
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 270 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 235 - 310
- Mortality:
- Two out of five males died following 63.1 mg/kg exposure to the test substance; Four out of five males died following 79.4 mg/kg exposure to the test substance; Three out of five males died following 100 mg/kg exposure to the test substance; Three out of five males died following 126 mg/kg exposure to the test substance; Four out of five males died following 158 mg/kg exposure to the test substance.
One out of five females died following 200 mg/kg exposure to the test substance; One out of five females died following 251 mg/kg exposure to the test substance; Four out of five females died following 316 mg/kg exposure to the test substance; - Clinical signs:
- other: Signs of intoxication in both sexes included: weight loss, increasing weakness, ocular discharge, tremors, convulsions, collapse and death. In females in addition to already listed signs, diarrhoea and dyspnoea were also observed.
- Gross pathology:
- In both sexes: haemorrhagic lungs, liver hyperthermia and discolouration in some instances, gastrointestinal inflammation (acute in some instances).
- Other findings:
- In survivors (14 days), viscera appeared normal in both sexes.
Any other information on results incl. tables
Acute oral toxicity in male rats.
Dose (mg/kg) | Mean initial weight (g) | Mortality out of five/dose |
50.1 | 230 | 0 |
63.1 | 235 | 2 |
79.4 | 245 | 4 |
100 | 240 | 3 |
126 | 240 | 3 |
158 | 235 | 5 |
Time of mortality: 1 -2 days post exposure. Slope 3.9
Acute oral toxicity in female rats.
Dose (mg/kg) | Mean initial weight (g) | Mortality out of five/dose |
158 | 245 | 0 |
200 | 245 | 1 |
251 | 245 | 1 |
316 | 235 | 4 |
Time of mortality: 1 -3 days post exposure. Slope 9.0
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The oral LD50 for males was 75 mg/kg bw and for females it was 270 mg/kg bw. The substance is therefore classified as category 3 for acute oral toxicity.
- Executive summary:
The substance was used in an acute oral toxicity study using male and female rats (n=5/sex). The male rats were orally exposed to 50.1, 63.1, 79.4, 100, 126, 158 mg/kg body weight of undiluted substance. The female rats were orally exposed to 158, 200, 251, 316 mg/kg body weight of undiluted substance. Two out of five males died following 63.1 mg exposure to the test substance. Four out of five females died following 316 mg/kg exposure to the test substance. The oral LD50 for males was 75 mg/kg bw and for females it was 270 mg/kg bw. The substance is therefore classified as category 3 for acute oral toxicity.
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