Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-076-4 | CAS number: 4645-32-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 September 1984 and 21 September 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Dimethyl vinylphosphonate
- EC Number:
- 225-076-4
- EC Name:
- Dimethyl vinylphosphonate
- Cas Number:
- 4645-32-3
- Molecular formula:
- C4H9O3P
- IUPAC Name:
- Dimethyl ethenylphosphonate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- SOURCE ANIMAL
- Source: HOECHST AG, Kastengrund
- Weight at study initiation: 2.1 - 3.4 kg
- Housing: individually
- Diet: ad libitum (deionised chlorinated water)
- Water: ad libitum (Altromin)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 2
- Humidity (%): 55 +/- 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- SOURCE ANIMAL
- Source: HOECHST AG, Kastengrund
- Weight at study initiation: 2.1 - 3.4 kg
- Housing: individually
- Diet: ad libitum (deionised chlorinated water)
- Water: ad libitum (Altromin) - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 30 - 60 min, 24 h, 48 h and 72 h
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap: patch containing the substance covered with a semi-occlusive bandage
OBSERVATION TIME POINTS
30 - 60 min, 24 h, 48 h and 72 h
SCORING SYSTEM:
- Method of calculation: according to Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Animal 1 and 2 showed dry and demure skin after 24 h and 48 h of the application as well as brown, small-area discolorations of the skin after 48 h of the test item application.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item is not considered to be irritating to rabbits' skin in a study according to OEC TG 404.
- Executive summary:
The test item was examined for skin irritation properties in a study with 3 albino New Zealand White rabbits according to OECD TG 404. The test material was applied to the shaved intact skin of rabbits as a single dose of 0.5 mL and covered with a semi-occlusive dressing. The irritation symptoms were examined at 30 – 60 min, 24, 48 and 72 hours after the patch removal. In all animals very slight erythema (score 1) were recorded 30 – 60 min and 24 hours after patch removal. Two animals showed also very slight erythema 48 hours after patch removal. All animals were free of irritation symptoms (erythema) 72 hours after patch removal. Thus, the study was terminated after 72 hours. No oedema were observed in any animal and at any time pont.
The animals' individual mean scores (considering readings at 24, 48 and 72 hours after patch removal) for erythema and oedema were 0.70, 0.70 and 0.30 and 0.00, 0.00 and 0.00 respectively.The observed symptoms were evaluated as fully reversible alterations.
Thus, the test item is not considered to be irritating to rabbits’ skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
