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Diss Factsheets
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EC number: 225-076-4 | CAS number: 4645-32-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1984 and October 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- 1979
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl vinylphosphonate
- EC Number:
- 225-076-4
- EC Name:
- Dimethyl vinylphosphonate
- Cas Number:
- 4645-32-3
- Molecular formula:
- C4H9O3P
- IUPAC Name:
- Dimethyl ethenylphosphonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund
- Weight at study initiation: 164 - 205 g (males); 162-193 g (females)
- Fasting period before study: 16 hours before application
- Housing: in groups of 5 in macrolon cages
- Diet: ad libitum (Altromin 1324)
- Water: ad libitum (tap water)
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 55 +/- 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25% (w/v)
MAXIMUM DOSE VOLUME APPLIED: 5.0 mL/kg bw
DOSAGE PREPARATION: The test item was diluted in water to a concentration of 25% (w/v). - Doses:
- 315, 500, 560, 630, 800, 1000 and 1250 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopically examinations - Statistics:
- - Probit analysis according to Lindner and Weber
- method according to Fieller or Sidak
Results and discussion
- Preliminary study:
- No details on preliminary study.
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 858 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 602 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 630 mg/kg bw: 3/5 (females)
800 mg/kg bw: 2/5 (males); 5/5 (females)
1000 mg/kg bw: 4/5 (males)
1250 mg/kg bw: 5/5 (males) - Clinical signs:
- Clinical signs were observed in male and female rats. On day of application occured squatting position, draftee flanks, tumbling gait, calm behaviour, pilorection. One day after application prone position, trembling, tonic cramping, jumping cramps, blood coloured lacrimation, blood stained snouts and increased breathing frequency were observed. One male had temporarily light brown-coloured decay.
- Body weight:
- No changes were observed.
- Gross pathology:
- The decendents animals showed the following findings: hemorrhages in the stomach, stomach content was darkly coloured (brown), small intestine filled with yellow or reddish brown thin fluid mass, lungs filled with blood, lung was bright red, spleen was lightened, spleen was strongly diminished, pancreas was dark red and both kidneys were lightened. In one high dose male animal, liver was strongly diminished. The stomach of this animal was deformed, the urinary bladder bulging, both adrenal glands darkened, and the epididymis reddish. Animals killed at the end of the observation period were free of macroscopically visible changes.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 value of the test item was determined to be 858.0 mg/kg bw in males and 602 mg/kg bw in females.
- Executive summary:
The acute oral toxicity of the test item was investigated in a study according to OECD TG 401 and EU Method B.1. Five animals each were exposed to the test item by oral gavage at doses ranging from 315 ranging from 1250 mg/kg bw. Animals were observed for 14 days. Mortality occured in 3 of 5 females at 630 mg/kg bw, in 2 of 5 males and 5 of 5 females at 800 mg/kg bw, 4 of 5 males at 1000 mg/kg bw and 5 of 5 males at 1250 mg/kg bw. Clinical were observed in both male and female animals on day of application and one day after application. The body weight was not affected. The decendents animals showed the following macrosopic findings. Animals killed at the end of the observation period were free of macroscopically visible changes. Based on the available data, the LD50 value of the test item was determined to be 858.0 mg/kg bw in males and 602 mg/kg bw in females.
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