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EC number: 237-525-1 | CAS number: 13826-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from online Chemical Repository Database
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Primary skin irritation study was performed on New Zealand White rabbits for 72 hrs.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-phenoxybenzylic alcohol
- EC Number:
- 237-525-1
- EC Name:
- 3-phenoxybenzylic alcohol
- Cas Number:
- 13826-35-2
- Molecular formula:
- C13H12O2
- IUPAC Name:
- (3-phenoxyphenyl)methanol
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 3-Phenoxybenzyl alcohol
- Molecular formula (if other than submission substance): C13H12O2
- Molecular weight (if other than submission substance): 200.23318 g/mol
- Smiles notation (if other than submission substance): C1=CC=C(C=C1) OC2=CC=CC (=C2) CO
- InChl (if other than submission substance): InChI=1S/C13H12O2/c14-10-11-5-4-8-13(9-11)15-12-6-2-1-3-7-12/h1-9, 14H, 10H2
- Substance type: Organic
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: The Ethyl Corporation, Ferndale, Michiga
- Age at study initiation: No data available
- Weight at study initiation: 2031 to 2251 grams
- Fasting period before study: No data available
- Housing: In hanging wire-mesh cages
- Diet (e.g. ad libitum): Purina Rabbit Chow(ad libitum)
- Water (e.g. ad libitum): Water(ad libitum)
- Acclimation period: No data available
Or Test Tissue
- Source: not applicable
- Type: not applicable
- Acclimation : not applicable
- Housing conditions: not applicable
ENVIRONMENTAL CONDITIONS
- Temperature (°C): kept in temperature controlled quarters
- Humidity (%):kept in humidity controlled quarters
- Air changes (per hr):No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Test system
- Type of coverage:
- other: Gauze bandaging and occluded with Saran Wrap
- Preparation of test site:
- other: shaved and clipped
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 milliliter of the test material
- Duration of treatment / exposure:
- 72 hrs
- Observation period:
- 4,24, 48 and 72 hrs
- Number of animals:
- 6 rabbits (3 male and 3 female)
- Details on study design:
- TEST SITE
- Area of exposure: back of each rabbit
- % coverage: 20-30% of the body surface
- Type of wrap if used: Sites were then covered with gauze bandaging and occluded with Saran Wrap.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Four hours later the bandages were removed and the sites were washed with tepid tap water and examined for skin irritation
- Time after start of exposure:4, 24, 48 and 72 hours
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hrs.
- Score:
- 0.2
- Max. score:
- 8
- Reversibility:
- no data
Any other information on results incl. tables
Individual Rabbit Scores and Score Calculation
Intact skin |
||||||||
|
Erythema |
Edema |
||||||
Observation (Hours) |
Observation (Hours) |
|||||||
Animals No./Sex |
4 |
24 |
48 |
72 |
4 |
24 |
48 |
72 |
Male |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Female |
0 |
1.0 |
0 |
0 |
0 |
0 |
0 |
0 |
Female |
0 |
1.0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
|
|
Total |
0 |
2.0 |
0 |
0 |
0 |
0 |
0 |
0 |
Abraded Skin |
||||||||
|
Erythema |
Edema |
||||||
Observation (Hours) |
Observation (Hours) |
|||||||
Animals No./Sex |
4 |
24 |
48 |
72 |
4 |
24 |
48 |
72 |
Male |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Male |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Female |
0 |
1.0 |
0 |
0 |
0 |
1.0 |
0 |
0 |
|
|
|
|
|
|
|
|
|
Total |
0 |
1.0 |
0 |
0 |
0 |
1.0 |
0 |
0 |
Calculation for Primary Skin Irritation Score (Score = the average of all the erythema scores plus the average of all the edema scores): (3.0 /24) + (1.0/ 24) = 0.2.
Number of Animals Exhibiting Signs with Scoring "Value"
|
|
Intact Skin |
Abraded Skin |
||||||
|
Observation (Hours) |
Observation (Hours) |
|||||||
Observations |
Value |
4 |
24 |
48 |
72 |
4 |
24 |
48 |
72 |
Erythema, Eschar Formation |
0 |
3/3 |
1/3 |
3/3 |
3/3 |
3/3 |
2/3 |
3/3 |
3/3 |
1 |
|
2/3 |
|
|
|
1/3 |
|
|
|
2 |
|
|
|
|
|
|
|
|
|
3 |
|
|
|
|
|
|
|
|
|
4 |
|
|
|
|
|
|
|
|
|
Edema Formation |
0 |
3/3 |
3/3 |
3/3 |
3/3 |
3/3 |
2/3 |
3/3 |
3/3 |
1 |
|
|
|
|
|
1/3 |
|
|
|
2 |
|
|
|
|
|
|
|
|
|
3 |
|
|
|
|
|
|
|
|
|
4 |
|
|
|
|
|
|
|
|
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The endpoint for the 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) for New Zealand white rabbits were found to be non- skin irritating.
- Executive summary:
Primary skin irritation study in the albino rabbit was performed with 3-Phenoxybenzylalcohol. 6 animals (3 male/ 3 female) used for the study with 2031 to 2251 grams at beginning of the study. They were housed in hanging wire-mesh cages in temperature and humidity controlled quarters.The hair was removed from the back of each rabbit with an electric clipper. The skin of 3 of the rabbits was abraded with a scalpel blade.0.5 milliliter of the test material was applied to the back of each rabbit and covered with gauze bandaging and occluded with saran wrap.Four hours later the bandages were removed and the sites were washed with tepid tap water and examined for skin irritation with 24, 48 and 72 hours.
From the individual rabbit scores and the computed primary irritation score it was found to be 0.2 which exit between the ranges 0.1-0.5.
Therefore, the endpoint for the 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) for the New Zealand white rabbits were found to be non- skin irritating.
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