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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Internal report, no full test report available. However, all relevant information is given. Therefore, the study can be regarded as valid for assessment.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1978

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
1 New Zealand albino rabbit (male or female) were exposed to 1 of 4 concentrations over a period of 24 h. Substance was applied undliuted and post exposure period was 14d.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
2000, 3160, 5010, and 7940 mg/kg bw
No. of animals per sex per dose:
1
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 160 mg/kg bw

Any other information on results incl. tables

Mortalities

Dose (mg/kg)

male

female

combined

2000

0/1

0/1

3160

0/1

0/1

5010

1/1 (3 d)

1/1

7940

1/1 (2 d)

1/1

Signs of intoxication were weight loss (2 -4 days in survivors), increasing weakness, collapse, and death.

Gross autopsy: Decedents: hemorrhagic areas of the lungs, liver discoloration, enlarged gall bladder, darkened kidneys and spleen, and gastrointestinal inflammation. Survivors (14d): Visccera appeared normal.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was >3160 mg/kg after a expusure of New Zealand albino rabbits for 24h. 1 New Zealand albino rabbit (male or female) were exposed to 1 of 4 concentrations over a period of 24 h. Substance was applied undliuted and post exposure period was 14d.
Executive summary:

1 New Zealand albino rabbit (male or female) were exposed to 1 of 4 concentrations over a period of 24 h. Substance was applied undiluted and post exposure period was 14d.