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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data sheet with overview of serveral studies, no full test report available. However, all relevant information is given. Therefore, the study can be regarded as valid for assessment.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1985

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
6 male albino rats were exposed to one concentration. Post exposure period was 14 d.
GLP compliance:
not specified
Test type:
fixed concentration procedure

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: Albino
Sex:
male

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
1 h
Concentrations:
22.1 mg/L
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC0
Effect level:
22.1 mg/L air
Exp. duration:
1 h
Sex:
male
Dose descriptor:
LC0
Effect level:
4 510 ppm

Any other information on results incl. tables

No animals died at a cumene concentration of 22.1 mg/L (exposure period 1 h, post exposure period 14 d). The animals were exposed at room-temperature . The total air flow rate was 10.0 lpm. Signs of toxicity were observed 0 -15 min after exposure started. These signs included excitation, laszimation, hyperpnea, tremors, fibrillary action, ataxia, prostation and sedation. All animals recovered within the first day after end of exposure. Gross autopsy of survivors revealed no significant findings.

Applicant's summary and conclusion

Conclusions:
No toxicity was observed in male albino rats exposed to cumene at 22.1 mg/L over a period of 1h.