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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Description of key information

Three reliable studies on long-term effects of cumene on aquatic green algae are available performed according to OECD 201 and two of the studies are conducted under GLP (Lebertz 2010, APA/CEFIC 1998). The effects were studied using sealed flasks. Measured concentrations were used for the evaluations. The lowest relevant 72 h EC50 value for the hazard assesment and classification & labelling is based on growth rate: 2.01 mg/L (Lebertz 2010).  The NOEC for growth rate obtained in this study is 1.49 mg/L.

Key value for chemical safety assessment

EC50 for freshwater algae:
2.01 mg/L
EC10 or NOEC for freshwater algae:
1.49 mg/L

Additional information

Data on effects of cumene in aquatic algae is presented in EU RAR (2001) in Section 3.2.1.1 (Aquatic compartment (incl. Sediment), page 25ff).

Three reliable studies on long-term effects of cumene on aquatic green algae are available performed according to OECD 201 and two of the studies were conducted under GLP (P&D 2010, APA/CEFIC 1998). The effects were studied using sealed flasks due to the volatility of cumene. Mean measured concentrations were used for the evaluations. The 72 h EbC50 values based on biomass are 1.29 (P&D 2010), 2.6 (Galassi et al., 1988) and 2.6 mg/L (APA/CEFIC 1998). The ErC50 and ErC10 for growth rate was 2.01 mg/L and 1.35 mg/L, respectively, and the NOEC relevant for the long-term assessment, was 1.49 mg/L in the GLP study of P&D (2010).

Using the data from the GLP study (APA/CEFIC 1998) the ErC50 was calculated to be 4.27 mg/L and the ErC10 was 3.36 mg/L. The NOEC for growth rate was recalculated by the reviewer to be 2.4 mg/L. The results support the findings obtained in the study of P&D (2010). The data of the latter study are used as key values for the chemical safety assessment, since they are the most reliable and the lowest values out of the available studies (ErC50 2.01mg/L and NOEC 1.49 mg/L).