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EC number: 407-430-1 | CAS number: 3741-80-8 CP22595; SANTOCURE TBS1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Two independent studies were carried out to determine the short term toxicity of TBSI (CAS 3741-80-8) to Daphnia magna and Ceriodaphnia dubia. The Daphnia magna study gave the lowest value for a short term effect, resulting in a 48h EC50 value of 5 µg/L. From the Ceriodaphnia dubia study a 48h EC 50 value of 496 ug/L was derived.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 5 µg/L
Additional information
The result of the test with Daphnia magna is very low compared to the result obtained for Ceriodaphnia dubia. Daphnia magna might be more sensitive to TBSI, but also if the result of the Daphnia magna test is compared with the long term daphnid studies (which are also based on Daphnia magna) it is very low. But as no obvious flaws in either study is present the lowest result, based on the Daphnia magna test is taken as the relevant 48h EC50 value that is used in further evaluations.
The result of the Ceriodaphnia dubia static study is consistent with the static renewal study, which is described in the same report. The lowest test concentration with an effect in the static test was well above the highest concentration in the static renewal test. So based on this result no effect should be anticipated in the static renewal test. Therefore the conclusion of the authors that the lack of observed effects could be caused by adsorption of the test material to plastic stoppers, which could have affected the bio-availability of the test compound is irrelevant.
As the test with Ceriodaphnia dubia was based on nominal concentrations it is very likely that hydrolysis products have played a role in the test result, as TBSI is assumed to rapidly break down. No mention of this is made in this study, but the consistent result in the static test and the static renewal test indicate that this did not have a dramatic effect on the results.
The flow through study with Daphnia magna is based on measured concentrations that deviated considerably with the nominal concentrations (also measured concentrations in the stock solutions were considerably lower than nominal concentrations). Therefore it is very likely that also in this study hydrolyses products will have played a role in the result, even though this test was carried out as a flow through test.
Based on these results, the lowest value of the two tests is taken for further evaluation; the 48 h EC50 value for short term effects on invertebrates is 5 µg/L.
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