Registration Dossier
Registration Dossier
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EC number: 407-430-1 | CAS number: 3741-80-8 CP22595; SANTOCURE TBS1
Endpoint summary
Administrative data
Description of key information
Additional information
The aquatic toxicity of TBSI is influenced by its hydrolysis products as TBSI is assumed to be rapidly hydrolysed to its final degradation products MBT and t-butylamine. t-butylamine has a relatively low toxicity so the aquatic toxicity of TBSI is determined by its degradation products MBT and structural analogue TBBS (which could also be an intermediately formed metabolite).
For TBSI itself short term aquatic toxicity tests were conducted:
1. 96 hour flow-through toxicity test on fathead minnow (Pimephales promelas)
2. 48 hour toxicity test on Daphnia magna
3. 48 hour toxicity test on Ceriodaphnia dubia
4. 96 hour toxicity test to Selenastrum capricornutum Printz
additional short term and long term toxicity data for fish and daphnids are present for the degradation compounds MBT, and structural analogue TBBS which are used in a read across approach. Long-term:
1. 89 days flow-through toxicity test on Oncorhynchus mykiss (previous name: Salmo gairdneri)
2. 21 days static toxicity test on daphnia magna
From the data it appeared that the test of TBSI on Daphnia magna was the most critical result for short-term. The lowest effect concentration based on long-term data from MBT is 0.041 mg/L (fish, 89d) and this value was used as a starting point for the derivation of the PNECs.
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