Registration Dossier
Registration Dossier
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EC number: 239-106-9 | CAS number: 15022-08-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 14, 2001 to August 6, 2003
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non GLP-compliant screening study according to (not specified) OECD test guidelines principles and procedures of the GLP-regulations 1999/11/EC and Italian Decreto Legislativo 27 Gennaio 1992 n. 120
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- screening test
- Deviations:
- yes
- GLP compliance:
- no
Test material
- Reference substance name:
- Diallyl carbonate
- EC Number:
- 239-106-9
- EC Name:
- Diallyl carbonate
- Cas Number:
- 15022-08-9
- Molecular formula:
- C7H10O3
- IUPAC Name:
- bis(prop-2-en-1-yl) carbonate
- Details on test material:
- - Name of test material (as cited in study report): DAC
- Physical state: colourless liquid
- Lot/batch No.: 011009
- Expiration date of the lot/batch: October 9, 2002
- Storage condition of test material: ambient conditions
- Other: RTC reference number 5979
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Controls:
- no
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- one (1)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- screening test, one animal only tested
- Time point:
- other: hours after exposure: 1, 24, 48, 72
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: no irritant effect
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- screening test, one animal only tested
- Time point:
- other: hours after exposure: 1, 24, 48, 72
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: no irritant effect
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The results indicate that the test item has no irritating effect on the skin of the rabbit.
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