Registration Dossier
Registration Dossier
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EC number: 204-557-2 | CAS number: 122-60-1
Carcinogenicity
Administrative data
Description of key information
IARC Summary on carcinogenicity studies with CAS 122-60-1
Key value for chemical safety assessment
Carcinogenicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 0.006 µg/m³
Justification for classification or non-classification
Additional information
The carcinogenicity studies can be summarized as follows (cf. IARC monograph 47):
Groups of 100 male and 100 female Sprague-Dawley rats, six weeks old, were exposed to 0, 1 or 12 ppm (6 or 73.5 mg/m3) phenyl glycidyl ether vapour (purity, 99.6% with trace amounts of phenol and diglycidyl ether) by inhalation for 6 h per day, on five days per week for 24 months. (No data were given on survval or bo weights.) Epidermoid carcinomas ocrred in the anterior parts of the nasal cavity in 1/89 male and 0/87 female controls, in 0/83 male and 0/88 female low-dose rats and in 9/85 male fp = 0.(07) and 4/89 fp = 0.06) female high-dose rats. The first nasal tumour was observed in week 89. ln the group receiving 12 ppm, squamous metaplasia, rhinitis, epithelial desquamation, regeneration, hyperplasia and dysplasia of the respiratoiy epithelium were also observed, especially in the anterior parts of the nasal cavity. No such increase in non-neoplastic changes ocurred in the group receiving 1 ppm.
Lee, KP., Schneider, P.W, Ir & Trochimowicz, H.J. (1983) Morphologic expression of glandular differentiation in the epidermoid nasal cacinomas induce by phenylglycidyl ether inhalation. Am. J. Pathol, 111, 140 -148.
Carcinogenicity: via inhalation route (target organ): respiratory: nose
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