2,3-epoxypropyl phenyl ether

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1954

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Scientific publications and secondary literature with restrictions compared to Guideline Study (limited documenta

Data source

Reference

Reference 1

Reference Type:

publication

Title:

The toxicology of glycidol and some glycidyl ethers

Author:

Anderson, H. H. Dunlap, M. K. Hine, C. H. Kodama, J. K. Wellington, J. S.

Year:

1956

Bibliographic source:

Anderson, H. H., M. K. Dunlap, et al. (1956). The toxicology of glycidol and some glycidyl ethers. Archives of industrial health 14(3): 250-264.

Reference 2

Reference Type:

publication

Title:

Range-finding toxicity data: List V

Author:

Smyth HF, Carpenter CP, Weil CS, Pozzani UC

Year:

1954

Bibliographic source:

Arch. Ind. Hyg. Occupational Med. 10, 61-68

Reference 3

Reference Type:

secondary source

Title:

MAK Begrüngung - Phenylglycidyl ether

Author:

MAK Kommission

Year:

1991

Bibliographic source:

MAK Begrüngung - Phenylglycidyl ether (1991)

Report date:

1991

Reference 4

Reference Type:

publication

Title:

No information

Year:

1978

Bibliographic source:

Reichhold Chemicals Inc., Studies submitted under section 8 (d) of the TSCA, U. S. EPA 8 DHQ-0878–0007, 1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Automatically generated during migration to IUCLID 6, no data available

IUPAC Name:

Automatically generated during migration to IUCLID 6, no data available

Details on test material:

Name: Phenylglycidyl ether
CAS: 122-60-1
Synonyms: PGE; Phenoxypropenoxide; 2,3-

Test animals / tissue source

Species:

rabbit

Test system

Vehicle:

not specified

Amount / concentration applied:

no data

Duration of treatment / exposure:

no data

Observation period (in vivo):

no data

Number of animals or in vitro replicates:

6

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

cornea opacity score

Basis:

mean

Time point:

other: 24 - 48 - 72 hours

Score:

0.1

Max. score:

4

Reversibility:

not specified

Results 2

Irritation parameter:

iris score

Basis:

mean

Time point:

other: 24 - 48 - 72 hours

Score:

0

Max. score:

2

Reversibility:

not specified

Results 3

Irritation parameter:

conjunctivae score

Basis:

mean

Time point:

other: 24 - 48 - 72 hours

Score:

1.3

Max. score:

3

Reversibility:

not specified

Results 4

Irritation parameter:

chemosis score

Basis:

mean

Time point:

other: 24 - 48 - 72 hours

Score:

1.4

Max. score:

4

Any other information on results incl. tables

Application of 0.1 mL PGE undiluted in rabbit eye, observation after 1, 24, and 48 hours.

Reference #1: mild irritation

Reference #2: Grade 2 on a scale of 10 grades

Reference #3: citation of Reference 1, and Reference 2.

Reference #4:

Scoring System form Ref #4:

SCORING SYSTEM: according the gradings listed in OECD guideline 405, additionally gradings for the "aera of cornea involved" and "discharge" were given:
Area of cornea involved:
One quarter (or less), but not zero: 1
Greater than one quarter, but less than half: 2
Greater than half, but less than three quarters: 3
Greater than three quaters, to whole cornea: 4

Discharge:
No discharge: 0
Any amount different from normal: 1
Discharge with moistening of the lids and hairs just adjacent to lids: 2
Discharge with moistening of the lids and hairs, and considerable area around eye: 3