Registration Dossier
Registration Dossier
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EC number: 204-557-2 | CAS number: 122-60-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientific publication with restrictions compared to Guideline Study (limited documentation)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Evaluation of acute toxicity of phenyl glycidyl ether with special regard to percutaneous absorption
- Author:
- Czajkowska T and Stetkiewicz J
- Year:
- 1 972
- Bibliographic source:
- Med Pr 23, 363-371 cited also in BG Chemie report No 65
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- limited documentation
- Principles of method if other than guideline:
- limited documentation
- GLP compliance:
- no
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Name of test material: phenyl glycidyl ether
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- single dermal application
- Duration of exposure:
- No data
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Details on study design:
- - observation period 14 days
- histopathology examinations performed - Statistics:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 160 mg/kg bw
- Based on:
- test mat.
- Other findings:
- 18 hours after treatment, histopathological examination of the skin revealed necrosis, epithelial exfoliation and oedema.
After 14 days, scar formation, acanthosis and swelling of the dermis were seen.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
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