N,N-dimethylaniline

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VI

Author:

Smyth, H.F. et al

Year:

1962

Bibliographic source:

American Industrial Hygiene Association Journal. Volume 23, Issue 2, page 95

Reference 2

Reference Type:

other: Authoritative data base

Title:

CESARS Record no.: 209

Author:

CESARS database

Year:

2011

Bibliographic source:

CESARS (Chemical Evaluation Search and Retrieval System ); Smyth, H.F., et al. 1962. Range-finding toxicity data. American Ind. Hyg. Assoc. J. 23(6):95-107

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Principles of method if other than guideline:

Groups of 4 male New Zealand rabbits (weight 2.5 to 3.5 kg) were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours.

GLP compliance:

not specified

Test type:

other: technique similar to the Draize method.

Test material

Test material information

Constituent 1

Reference substance name:

N,N-dimethylaniline

EC Number:

204-493-5

EC Name:

N,N-dimethylaniline

Cas Number:

121-69-7

Molecular formula:

C8H11N

IUPAC Name:

N,N-dimethylaniline

Test material form:

other: oily

Details on test material:

- Name of test material (as cited in study report): N,N-dimethylaniline
- Substance type: Organic
- Physical state: liquid

Test animals

Species:

rabbit

Strain:

other: New Zealand

Sex:

male

Details on test animals or test system and environmental conditions:

New Zealand rabbits (weight 2.5 to 3.5 kg)

Administration / exposure

Type of coverage:

occlusive

Vehicle:

not specified

Details on dermal exposure:

Groups of 4 male albino New Zealand rabbits (weight 2.5 to 3.5 kg) were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours.

Duration of exposure:

24 hrs.

Doses:

no data

No. of animals per sex per dose:

4

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

1 692 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Other details not available

Mortality:

The LD50 was reported as 1.77 mL/kg, with a standard deviation range of 1.09 to 2.86 mL/kg.
Conversion to mg/kg used the specific gravity of 0.956 at 20/4°C.

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute toxicity by dermal route was examined on the groups of 4 male New Zealand rabbits. All animals were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours. In this study, lethal dose (LD50) concentration was found to be 1692 mg/kg.

Executive summary:

The acute toxicity by dermal route was examined on the groups of 4 male New Zealand rabbits. All animals were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours.

The lethal dose (LD50) was found to be 1.77 mL/kg, with a standard deviation range of 1.09 to 2.86 mL/kg. Conversion to mg/kg used the specific gravity of 0.956 at 20/4°C.

Hence, Dermal toxicity of N,N-dimethylaniline (LD50) was found to be 1692 mg/kg body weight. This value indicates that N,N-dimethylaniline is classified as category IV for acute toxicity through dermal route.