Registration Dossier
Registration Dossier
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EC number: 204-493-5 | CAS number: 121-69-7
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Data for N,N-Dimethylaniline
- Author:
- Gosselin, R.E., R.P. Smith, H.C. Hodge.
- Year:
- 1 984
- Bibliographic source:
- Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-209
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Study obtained from Clinical Toxicology of Commercial Products. 5th edition
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N,N-dimethylaniline
- EC Number:
- 204-493-5
- EC Name:
- N,N-dimethylaniline
- Cas Number:
- 121-69-7
- Molecular formula:
- C8H11N
- IUPAC Name:
- N,N-dimethylaniline
- Details on test material:
- - Name of test material: N,N-dimethylaniline
- Substance type: Organic
- Physical state: liquid
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- other: no data
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- not reported
- Doses:
- not reported
- No. of animals per group:
- not reported
Results and discussion
Percutaneous absorption
- Remarks on result:
- other: Readily absorbed through intact skin to produce dangerous methemoglobinemia
Applicant's summary and conclusion
- Conclusions:
- N,N-dimethylaniline is readily absorbed through intact skin to produce dangerous methemoglobinemia
- Executive summary:
N,N-dimethylaniline is readily absorbed through intact skin to produce dangerous methemoglobinemia.
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