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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
The basis for this read-across approach is that the target substance is expected to undergo transformation into terephthalic acid (CAS No. 100-21-0) and ethane-1,2-diol (CAS No. 107-21-1). The toxicity of the transformation products will accurately predict the toxicity of the bis(2-hydroxyethyl)terephthalate (CAS No. 959-26-2). Refer to the JUSTIFICATION FOR READ-ACROSS OF TOXICOLOGICAL INFORMATION in Section 13 of this dossier for further details.
Reason / purpose for cross-reference:
read-across: supporting information
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Specific details on test material used for the study:
Prediction based on the toxicity of the transformation products terephthalic acid (100-21-0) and ethylene glycol (107-21-1)
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
> 1 530 mg/L
Basis for effect:
growth rate
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
> 6 mmol/L
Basis for effect:
growth rate
Details on results:
The 96h ErC50 for terephthalic acid is reported as > 1000 mg/L (96h ErC50 > 6.0 mmol/L).

The 96h IC50 for ethylene glycol is reported as 10940 mg/L (96h IC50 = 176.3 mmol/L)

Based on a conservative prediction, the 96h ErC50 of BHET is predicted to be > 1530 mg/L (96h ErC50 > 6.0 mmol/L).
Validity criteria fulfilled:
not applicable
Remarks:
Prediction based on analogue approach
Conclusions:
Based on a conservative prediction, the 96h ErC50 of BHET is predicted to be > 1530 mg/L.
Executive summary:

No data regarding effects on the growth of aquatic plants was available for BHET. The effects on the growth of aquatic plants for terephthalic acid was assessed in Desmodesmus subspicatus in a GLP-compliant study according to OECD 201. The reported 96h ErC50 was greater than 1 000 mg/L or greater than 6.0 mmol/L. The ability of ethylene glycol to inhibit the growth of Raphidocelis subcapitata was assessed in an US EPA/600/4-89/01 Short-term method for estimating chronic toxicity of effluents and receiving waters to freshwater organisms. The reported 96h IC50 was 10 940 mg/L or 176.3 mmol/L. Information on the source substances is considered to be directly applicable to an equivalent molar amount of the target substance; therefore, the 96h ErC50 of BHET was predicted to be greater than 6.0 mmol/L or greater than 1 530 mg/L.

Description of key information

Based on a conservative prediction, the 96h ErC50 of BHET is predicted to be > 1530 mg/L.

Key value for chemical safety assessment

EC50 for freshwater algae:
1 530 mg/L

Additional information