Registration Dossier
Registration Dossier
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EC number: 256-917-3 | CAS number: 51022-74-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- intracerebral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Study of Medical Supplies
- Author:
- Kenkyu I.
- Year:
- 1 970
- Bibliographic source:
- Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan V.1- 1970-
Materials and methods
- Principles of method if other than guideline:
- Abstract, information on materials and methods are not available.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Iotroxic acid
- EC Number:
- 256-917-3
- EC Name:
- Iotroxic acid
- Cas Number:
- 51022-74-3
- Molecular formula:
- C22H18I6N2O9
- IUPAC Name:
- 3-{2-[2-(2-{[(3-carboxy-2,4,6-triiodophenyl)carbamoyl]methoxy}ethoxy)ethoxy]acetamido}-2,4,6-triiodobenzoic acid
Constituent 1
- Specific details on test material used for the study:
- no data
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- other: intracerebral
- Vehicle:
- not specified
- Details on exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- LD50 determination
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 50 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no data
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Conclusions:
- In this study, the LD 50 of Iotroxic acid after intracerebral application in mice was determined to be 50 mg/kg bw.
- Executive summary:
In an acute toxicity study, mice were given intracerebral a single dose of Iotroxic acid. Based on the results, a LD50 of 50 mg/kg bw was determined.
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