Iotroxic acid

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-02-08 to 2018-05-18

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

GLP compliance:

no

Type of method:

other: Differential scanning calorimetry and capillary method

Key result

Decomposition:

yes

Remarks on result:

other: No boiling point under atmospheric conditions

Boiling point / Boiling range range: DSC measurement

A DSC measurement showed a multistage endothermal effect in the temperature range of 100 - 230 °C with no clear melting point (onset). The endothermal effect was followed by an exothermal effect in the temperature range of 240 - 300 °C. The result of the DSC measurement is shown in Table 1.

Table 1: Results of the DSC measurement

Test item / mg	Starting temperature / °C	Final test temperature / °C	Temperature range (endothermal) / °C	Onset (melting) / °C	Crucible	Observations after the measurement
12.52	25	500	100 – 230	Multi-stage	Aluminium with hole	Black residue

Boiling point / boiling range: Capillary tube in a metal block

The results of the capillary method are shown in Table 2.

Table 2: Results of the capillary method

Set point / °C	Heating rate / K/min	End point / °C	Remarks
50	10	230	Approx. 122 °C: test item started to melt Approx. 182 °C: test item was completely melted and turbid Approx. 199 °C: test item was a clear melt with small bubbles Approx. 224 °C: test item discoloured to orange, increasing formation of small bubbles Approx. 230 °C: no further change

The DSC measurement showed that the test item melted under decomposition. Therefore it can be concluded that the test item had no boiling point under atmospheric conditions.

Conclusions:

The test item melted under decomposition. Therefore it can be concluded that the test item had no boiling point under atmospheric conditions.

Executive summary:

The boiling point of the test item was determined by DSC measurement according to OECD test guideline 103. The test item melted under decomposition. Therefore it can be concluded that the test item had no boiling point under atmospheric conditions.

Description of key information

The boiling point of the test item was determined by DSC measurement according to OECD test guideline 103. The test item melted under decomposition. Therefore it can be concluded that the test item had no boiling point under atmospheric conditions.