Registration Dossier
Registration Dossier
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EC number: 234-634-6 | CAS number: 12018-10-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
Guidance on skin sensitisation testing stipulates that new in vivo tests on guinea pigs should no longer be conducted. It is, however, appropriate to make full use of existing data of this type. This is particularly the case for copper-containing compounds, given the known tendency for the preferred LLNA method to produce false positive results for these substances. Therefore, instead of generating new in vitro or LLNA data on copper dichromium tetraoxide, a read-across to existing data for the analogous substances copper oxide (CuO) and chromium oxide (Cr2O3) is proposed. Based on the results of the existing in vivo guinea pig studies on these substances, it is concluded that copper dichromium tetraoxide should not be classified on the basis of skin sensitisation potential.
Similarly, there is no indication based on read-across that copper dichromium tetraoxide should be classified as a respiratory sensitiser.
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