Registration Dossier
Registration Dossier
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EC number: 205-472-3 | CAS number: 141-24-2
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Only basic data given, no conclusion about guidelines and GLP status possible
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis
- Author:
- Secchi, A. G., M. S. Tognon, and A. Leonardi
- Year:
- 1 990
- Bibliographic source:
- Secchi, A. G., M. S. Tognon, and A. Leonardi.1990. Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis. Am J Ophthalmol 110:641– 645
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- eye irritation
- Principles of method if other than guideline:
- Eye irritation study with Castor oil.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Castor oil
- EC Number:
- 232-293-8
- EC Name:
- Castor oil
- Cas Number:
- 8001-79-4
- Molecular formula:
- not applicable, substance is UVCB
- IUPAC Name:
- Castor oil
Constituent 1
Method
- Subjects:
- - Number of subjects exposed: nine patients with vernal keratoconjunctivitis- Age: not stated
- Route of exposure:
- ocular
- Reason of exposure:
- intentional
- Details on exposure:
- One eye was treated with 2% cyclosporine in castor oil four times daily for 15 days. The other eye was treated with castor oil solution only according to the same procedure.
Results and discussion
- Results of examinations:
- Mild and transient discomfort and minor epithelial changes were observed in both eyes.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
