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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015-01-12 to 2015-01-17
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Test material information:
Composition 1
Key result
Water solubility:
19 g/L
Loading of aqueous phase:
250 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
4.4
Details on results:
Preliminary Test (nonGLP): The determined solubility was in the range of 20 - 50 g/L.

Water solubility results at 20°C for the test item

 

Preincubation time

Replicate No.

test item

Concentration1)

Mean

24 h

1

19.2

19.1

2

19.0

48 h

1

19.2

19.2

2

19.2

72 h

1

19.2

18.8

2

18.5

Mean (24-72 h)

 

19.0

Deviation [%](24-72)

1.9

1)        Mean value of double injections

Check of temperature:

Temperature at incubation phase, 30°C and thermostatisation phase, 20°C (measured hourly)

Intended temperature [°C]

Measured temperature [°C]

 

Min

Max

Mean value ± SD

30.0 ± 0.5

29.62

30.09

30.03 ± 0.06

20.0 ± 0.5

19.96

20.21

20.04 ± 0.06

Check of pH value of the test mixture

Test temperature [°C]

Preincubation time [h]

Replicate

Measured pH

 Mean value

20

24

1

4.501

4.4

2

4.343

48

1

4.444

2

4.457

72

1

4.304

2

4.471

 

Control

6.818

-

 No tyndall effect was detected during the incubation time.

Validity criteria were fulfilled: The concentration measured did not differ more than 15%, temperatures were kept constant within ± 0.5°C.

Conclusions:
The water solubility of the test item was determined to be 19.0 g/L (pH 4.4) at 20 ± 0.5 °C.
Executive summary:

The test item has a water solubility of 19.0 g/L (pH 4.4) at 20 ± 0.5 °C as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).

Description of key information

The water solubility is 19.0 g/L (pH 4.4) at 20±0.5°C.

Key value for chemical safety assessment

Water solubility:
19 g/L
at the temperature of:
20 °C

Additional information

The test item has a water solubility of 19.0 g/L (pH 4.4) at 20±0.5°C as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).