Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth H.F.; Carpenter, C.P.; Weil C.S.; Pozzani, U.C.; Striegel, J.A.
Year:
1962
Bibliographic source:
American Industrial Toxicity Data: List VI 23: 95 - 107
Reference Type:
secondary source
Title:
American Industrial Hygiene Association
Year:
1962
Bibliographic source:
http://www.safe.nite.go.jp/english/ghs/11-mhlw-0074e.html Original source: American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

Materials and methods

GLP compliance:
no
Test type:
traditional method
Limit test:
no

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Remarks on duration:
observation period 14 days
Concentrations:
nominal concentrations in an essentially logarithmic series with a factor of 2
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LCLo
Effect level:
0.772 mg/L air
Based on:
test mat.
Remarks on result:
other: equivalent to 250 ppm
Mortality:
1 death in 6 animals
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria