Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Toxicity and quantitative structure–activity relationships of nitriles based on Pseudokirchneriella subcapitata
Author:
Chun-Pin Huang, Yun-Ju Wang, Chung-Yuan Chen
Year:
2007
Bibliographic source:
Ecotoxicology and Environmental Safety 67 (2007) 439–446

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Sampling and analysis

Analytical monitoring:
no

Test organisms

Test organisms (species):
Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h

Test conditions

Test temperature:
24+/-1°C

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
19.34 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: 95% Cl 8.91-49.9 mg/l
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
10.91 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: dissolved oxygen
Remarks on result:
other: 95% Cl 6.45-22.35 mg/l
Reported statistics and error estimates:
Probit analysis was applied to determine the concentration-response relationship and the median effective concentration (EC50).

Applicant's summary and conclusion

Conclusions:
In a well reported 48 hour growth inhibition test with algae (Pseudokirchneriella subcapitata) the 48h EC50 based on growth rate was determined to be 19.34 mg/l.