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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Toxicity and quantitative structure–activity relationships of nitriles based on Pseudokirchneriella subcapitata
Author:
Chun-Pin Huang, Yun-Ju Wang, Chung-Yuan Chen
Year:
2007
Bibliographic source:
Ecotoxicology and Environmental Safety 67 (2007) 439–446

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroacetonitrile
EC Number:
203-467-0
EC Name:
Chloroacetonitrile
Cas Number:
107-14-2
Molecular formula:
C2H2ClN
IUPAC Name:
2-chloroacetonitrile

Sampling and analysis

Analytical monitoring:
no

Test organisms

Test organisms (species):
Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h

Test conditions

Test temperature:
24+/-1°C

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
19.34 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: 95% Cl 8.91-49.9 mg/l
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
10.91 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: dissolved oxygen
Remarks on result:
other: 95% Cl 6.45-22.35 mg/l
Reported statistics and error estimates:
Probit analysis was applied to determine the concentration-response relationship and the median effective concentration (EC50).

Applicant's summary and conclusion

Conclusions:
In a well reported 48 hour growth inhibition test with algae (Pseudokirchneriella subcapitata) the 48h EC50 based on growth rate was determined to be 19.34 mg/l.