Registration Dossier
Registration Dossier
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EC number: 204-274-4 | CAS number: 118-75-2
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to actual guideline/ standards; test procedure according to national standards
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
- Reference Type:
- review article or handbook
- Title:
- BUA Report 85, Ref. Hoechst, 1989e
- Author:
- Beratergremium für umweltrelevante Altstoffe der Gesellschaft Deutscher Chemiker (BUA)
- Year:
- 1 992
- Bibliographic source:
- Hirzel Verlag, Stuttgart
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetrachloro-p-benzoquinone
- EC Number:
- 204-274-4
- EC Name:
- Tetrachloro-p-benzoquinone
- Cas Number:
- 118-75-2
- Molecular formula:
- C6Cl4O2
- IUPAC Name:
- 2,3,5,6-tetrachloro-1,4-benzoquinone
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- activated sludge
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 455.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- 135 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC80
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 3h-EC50 was 455.5 mg/L, the 3h-EC20 was 135 mg/L.
- Executive summary:
In a 3-h toxicity study activated sludge from a domestic water treatment plant was exposed toChloranil (2,3,5,6-tetrachloro-1,4-benzoquinone)in accordance with EU Method C.11 and OECD Guideline 209. The study was not performed in compliance with GLP. Reliability grade 2 was assigned. Tested concentrations and existence of controls were not indicated. The 3h-EC20 was 135 mg/L. The 3h-EC50 was 455.5 mg/L.
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