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EC number: 235-231-8 | CAS number: 12136-78-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Sodium molybdate was tested negative for acute dermal and eye irritating properties in tests conducted according to OECD 404 and OECD 405. Sodium molybdate is used as read-across partner to Molybdenum disilicide.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 0.5 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 0.5 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- No irritation
- Other effects:
- None
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In conclusion, in an acute dermal irritation/corrosion study according to OECD 404, the read-across partner Sodium molybdate was found to be non-irritating.
- Executive summary:
In a primary dermal irritation study (OECD guideline 404) six female New Zealand white rabbits were dermally exposed to 0.5 g of Sodium molybdate for 4 hours to a body surface area of 2.5 cm² under semi-occlusive conditions. Animals then were observed for 0.5, 24, 48 and 72 hours. Sodium molybdate did not cause any skin effects and is considered under the conditions of this study as non toxic.
This information is used in a read-across approach in the assessment of the target substance.
For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
Reference
Table 1: Dermal reactions elicited by Sodium Molybdate | ||||||
Rabbit number* | E = Erythema | Day | ||||
O = Oedema | 1** | 2 | 3 | 4 | ||
2481 | E | 0 | 0 | 0 | 0 | |
O | 0 | 0 | 0 | 0 | ||
2482 | E | 0 | 0 | 0 | 0 | |
O | 0 | 0 | 0 | 0 | ||
2483 | E | 0 | 0 | 0 | 0 | |
O | 0 | 0 | 0 | 0 | ||
2484 | E | 0 | 0 | 0 | 0 | |
O | 0 | 0 | 0 | 0 | ||
2485 | E | 0 | 0 | 0 | 0 | |
O | 0 | 0 | 0 | 0 | ||
2486 | E | 0 | 0 | 0 | 0 | |
O | 0 | 0 | 0 | 0 |
*= only female animals were tested
**= approximately 30 minutes after removal of dressing
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 0.66
- Reversibility:
- fully reversible within: 3d
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.06
- Max. score:
- 0.33
- Reversibility:
- fully reversible within: 2d
- Irritant / corrosive response data:
- Eye irritation scores were recorded at 1, 24, 48, and 72 hours, and at 7 days after treatment. No corneal damage or iridial inflammation was seen throughout the observation period. A diffuse crimson-red colouration of the conjunctivae was seen one hour after instillation only in one animal. Mild conjunctival inflammation was observed in the remaining five animals. Conjunctival reactions had completely resolved in all animals one to three days after instillation.
- Interpretation of results:
- not irritating
- Conclusions:
- In conclusion, in an acute eye irritation/corrosion study according to OECD 405, Sodium molybdate is not an eye-irritant.
- Executive summary:
In a primary eye irritation study (OECD 405), 100 mg of Sodium molybdate was instilled into the conjunctival sac of one eye of each of six young adult New Zealand White rabbits (four males and two females). Animals were observed for 7 days. Irritation was scored by the method of Draize. Only very mild conjunctival reactions were observed, which were fully reversible within 2-3 days. In this study, Sodium molybdate is not an eye irritant.
This information is used in a read-across approach in the assessment of the target substance.
For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
Reference
Table 1: Mean values of each rabbit scored at 24, 48 and 72 hours after treatment with Sodium molybdate | |||||||||
Animal number | Opacity | Iritis | Conjunctival redness | Conjunctival oedema | |||||
2451 (male) | 0 | 0 | 0.33 | 0 | |||||
2523 (male) | 0 | 0 | 0.33 | 0 | |||||
2524 (male) | 0 | 0 | 0.66 | 0.33 | |||||
2525(male) | 0 | 0 | 0.33 | 0 | |||||
2526 (female) | 0 | 0 | 0 | 0 | |||||
2527 (female) | 0 | 0 | 0.33 | 0 | |||||
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data is available for Molybdenum disilicide (target substance). Thus, available data from Sodium molybdate was used in a read-across approach. Due to a lower water solubility of Molybdenum disilicide compared to Sodium molybdate the resulting bioavailability (toxicity potential) would also be expected to be lower. Therefore, the read across to the source substance Sodium molybdate is adequately protective. Details on the read-across rational are provided in section 13.
Sodium molybdate was tested negative for acute dermal and eye irritating properties in tests conducted according to OECD 404 and OECD 405. Based on the results from the read-across partner Sodium molybdate, Molybdenum disilicide can be considered as not irritating to the skin and eye.
Justification for classification or non-classification
The read across partner Sodium molybdate did not cause any skin and eye effects in an acute dermal and eye irritating study in accordance to OECD 404 and OECD 405. Based on the results from the read-across partner, no classification of Molybdenum disilicide is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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