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EC number: 232-489-3 | CAS number: 8052-41-3 A colorless, refined petroleum distillate that is free from rancid or objectionable odors and that boils in a range of approximately 148.8°C to 204.4°C (300°F to 400°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Petroleum hydrocarbon toxicity studies. III. Animal and human response to vapors of Stoddard solvent.
- Author:
- Carpenter CP, Kinkead ER, Geary Jr, Sullivan LJ, & King JM
- Year:
- 1 975
- Bibliographic source:
- Toxicol Appl Pharmacol, 32: 282-297.
- Reference Type:
- publication
- Title:
- Petroleum hydrocarbon toxicity studies. VIII. Animal and human response to vapors of "140° Flash Aliphatic Solvent".
- Author:
- Carpenter CP, Kinkead ER, Geary Jr, Sullivan LJ, & King JM
- Year:
- 1 975
- Bibliographic source:
- Toxicol Appl Pharmacol, 34: 413-429.
- Reference Type:
- publication
- Title:
- Petroleum hydrocarbon toxicity studies. XIV. Animal and human response to vapors of "High Aromatic Solvent".
- Author:
- Carpenter CP, Geary DL, Myers RC, Nachreiner DJ, Sullivan LJ, & King JM
- Year:
- 1 977
- Bibliographic source:
- Toxicol Appl Pharmacol, 41: 235-249.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Exposure to mice of 350 mg/m3 (56 ppm vapour) or 1200 mg/m3 (vapour plus aerosol) of dearomatized Stoddard solvent (140° Flash Aliphatic Solvent)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Stoddard solvent
- EC Number:
- 232-489-3
- EC Name:
- Stoddard solvent
- Cas Number:
- 8052-41-3
- Molecular formula:
- C10H22
- IUPAC Name:
- stoddard solvent
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Stoddard solvent (140° Flash Aliphatic Solvent)
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- six male Swiss-Webster mice
Test system
- Route of induction exposure:
- inhalation
- Route of challenge exposure:
- inhalation
- Vehicle:
- unchanged (no vehicle)
- Concentration:
- 350 mg/m, 1200 mg/m3 , 3200 mg/m3 , 4400 mg/m3, 10 000 mg/m3
- No. of animals per dose:
- six male Swiss-Webster mice
- Details on study design:
- Exposure to Swiss-Webster mice (vapour plus aerosol) at concentration of 350 mg/m, 1200 mg/m3 , 3200 mg/m3 , 4400 mg/m3, 10 000 mg/m3
Results and discussion
- Results:
- There was used respiratory depression in mice as an index of irritative response in the upper respiratory tract. Three of six male Swiss-Webster mice developed a decline in respiratory rate (below 50% of the normal rate) during 1 min of exposure to 10 000 mg/m3 (1700 ppm vapour and aerosols) of white spirit (Stoddard solvent; 15% aromatics). A similar decrease in respiratory rate did not occur at 4400 mg/m3 (770 ppm).
Exposure to mice of either 350 mg/m3 (56 ppm vapour) or 1200 mg/m3 (vapour plus aerosol) of dearomatized white spirit (140° Flash Aliphatic Solvent) did not induce respiratory tract irritation or change in respiratory rate
Applicant's summary and conclusion
- Interpretation of results:
- other: not respiratory irritation
- Conclusions:
- There was used respiratory depression in mice as an index of irritative response in the upper respiratory tract. Three of six male Swiss-Webster mice developed a decline in respiratory rate (below 50% of the normal rate) during 1 min of exposure to 10 000 mg/m3 (1700 ppm vapour and aerosols) of white spirit (Stoddard solvent; 15% aromatics). A similar decrease in respiratory rate did not occur at 4400 mg/m3 (770 ppm).
Exposure to mice of either 350 mg/m3 (56 ppm vapour) or 1200 mg/m3 (vapour plus aerosol) of dearomatized white spirit (140° Flash Aliphatic Solvent) did not induce respiratory tract irritation or change in respiratory rate
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