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EC number: 232-489-3 | CAS number: 8052-41-3 A colorless, refined petroleum distillate that is free from rancid or objectionable odors and that boils in a range of approximately 148.8°C to 204.4°C (300°F to 400°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
- Type of study / information:
- Single exposure, Inhalation, controlled exposure, Irritation
CNS effects - Endpoint addressed:
- eye irritation
- neurotoxicity
- other: CNS effects
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- nine volunteers (students) were exposed to 0, 204, 600, 1200 and 2400 mg/m3 (0, 34, 100, 200 and 400 ppm) and six students and nine painters were exposed to 0, 300 and 600 mg/m3 (0, 50 and 100 ppm) for a duration of 7 h to white spirit vapour (17% aromatics).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Stoddard solvent
- EC Number:
- 232-489-3
- EC Name:
- Stoddard solvent
- Cas Number:
- 8052-41-3
- Molecular formula:
- C10H22
- IUPAC Name:
- stoddard solvent
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Stoddard solvent vapour (17% aromatics).
Method
- Ethical approval:
- confirmed, but no further information available
- Details on study design:
- nine volunteers (students) were exposed to 0, 204, 600, 1200 and 2400 mg/m3 (0, 34, 100, 200 and 400 ppm) and six students and nine painters were exposed to 0, 300 and 600 mg/m3 (0, 50 and 100 ppm) for a duration of 7 h to white spirit vapour (17% aromatics).
- Exposure assessment:
- measured
- Details on exposure:
- nine volunteers (students) were exposed to 0, 204, 600, 1200 and 2400 mg/m3 (0, 34, 100, 200 and 400 ppm) and six students and nine painters were exposed to 0, 300 and 600 mg/m3 (0, 50 and 100 ppm) for a duration of 7 h to white spirit vapour (17% aromatics).
Results and discussion
- Results:
- The reporting of eye irritation was the most sensitive measure of effect. There was a significant dose-response relationship in the house painter group and in one group of students exposed up to 2400 mg/m3; there was a higher sensitivity in the house painters. Among students, a dose-related increase in irritation of the nose was noted from 600 to 2400 mg/m3.
In the study was found dose-related increased incidences of headache, tiredness and giddiness among nine students exposed up to 2400 mg/m3 (400 ppm).
Applicant's summary and conclusion
- Conclusions:
- The reporting of eye irritation was the most sensitive measure of effect. There was a significant dose-response relationship in the house painter group and in one group of students exposed up to 2400 mg/m3; there was a higher sensitivity in the house painters. Among students, a dose-related increase in irritation of the nose was noted from 600 to 2400 mg/m3.
In the study was found dose-related increased incidences of headache, tiredness and giddiness among nine students exposed up to 2400 mg/m3 (400 ppm).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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