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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species, other
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
Data is from authorative database
Qualifier:
according to
Guideline:
other: Refer below principle
Principles of method if other than guideline:
Environmental Bioconcentration of test substance 1H-benzimidazole was determine using log Kow of 1.32 and a regression derived equation.
GLP compliance:
not specified
Specific details on test material used for the study:
-IUPAC name: 1H-benzimidazole
- Name of test material (as cited in study report):Benzimidazole
- Molecular formula: C7H6N2
- Molecular weight: 118.1384 g/mol
- Substance type: Organic
- Physical state: Solid
Radiolabelling:
not specified
Vehicle:
not specified
Test organisms (species):
other: aquatic organisms
Route of exposure:
aqueous
Test type:
not specified
Water / sediment media type:
natural water: freshwater
Hardness:
No data
Test temperature:
No data
pH:
No data
Dissolved oxygen:
No data
TOC:
No data
Salinity:
No data
Conductivity:
No data
Details on test conditions:
No data
Nominal and measured concentrations:
No data
Reference substance (positive control):
not specified
Key result
Type:
BCF
Value:
2.1 dimensionless
Basis:
whole body w.w.
Calculation basis:
other: regression derived equation
Validity criteria fulfilled:
not specified
Conclusions:
From authorative database HSDB, an estimated BCF of 2.1 (dimensionless) was calculated for 1H-benzimidazole (i.e benzimidazol),using log Kow of 1.32 and a regression derived equation.
Executive summary:

Based on an experimental log/octanol water partition coefficient of 1.32, a bioconcentration factor of 2.1 (dimensionless)can be calculated for  1H-benzimidazole (i.e benzimidazol) using an regression derived equation. This BCF suggests the potential of target chemical (Cas no.51 -17 -2) for bioconcentration in aquatic organisms is low.

Description of key information

Based on an experimental log/octanol water partition coefficient of 1.32, a bioconcentration factor of 2.1 dimensionless can be calculated for  1H-benzimidazole (i.e benzimidazol) using an regression derived equation. This BCF suggests the potential of target chemical (CAS no.51 -17 -2) for bioconcentration in aquatic organisms is low.

Key value for chemical safety assessment

BCF (aquatic species):
2.1 dimensionless

Additional information

Four different studies which includes one experimental from authoritative database and remaining three from validated predicted databases for bioaccumulation endpoint of target chemical 1H-benzimidazole (CAS no. 51-17-2) are summarized as followed:

 

First study from experimental result from authoritative database (HSDB by US EPA; 2017) suggest the bio concentration factor (BCF) for 1H-benzimidazole is 2.1 (dimensionless) based on an experimental log/octanol water partition coefficient of 1.32 and using an regression derived equation. This BCF indicate the potential of target chemical (CAS no.51 -17 -2) for bioconcentration in aquatic organisms is low.

Above experimental result is supported by prediction report by BCFBAF (v3.00) model which indicate the estimated bio concentration factor (BCF) for 1H-benzimidazole is 3.451 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that 1H-benzimidazole is not expected to bio accumulate in the food chain.

Another predicted database, PBT profiler propose the Bioaccumulation factor (BCF) was predicted to be 3.4 L/kg wet-wt at 25 deg.C for test chemical 1H-benzimidazole.

Further, Scifinder database indicates the Bioconcentration factor (BCF) for target chemical 1H-benzimidazole to be 1.0 at pH 1-4; 1.29 at pH 5; 4.35 at pH 6; 5.72 at pH 7; 5.91 at pH 8;5.93 at pH 9 and 5.92 at pH 10 and temperature 25 deg.C. Based on the BCF concentration at all pH range i.e 1 -10 it is concluded that the test chemical 1H-benzimidazole is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

 

All predicted and experimental values for bioaccumulation is in the range of 1.0 -5.93 (L/kg or dimensionless) conclude the target chemical 1H-benzimidazole (CAS no. 51-17-2) is non bioaccumulative in aquatic environment as it does not exceed the BCF criteria of 2000.