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EC number: 200-081-4 | CAS number: 51-17-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data from handbook.
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The toxicity to fish study has been performed to evaluate the acute effects of chemical Benzimidazole in 24-hrs.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - IUPAC name: 1H-benzimidazole
- Name of test material (as cited in study report):Benzimidazole
- Molecular formula: C7H6N2
- Molecular weight: 118.1384 g/mol
- Substance type: Organic
- Physical state: Solid - Analytical monitoring:
- not specified
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant):2-Propanone or Ethanol
- Concentration of vehicle in test medium (stock solution and final test solution(s) or suspension(s) including control(s)):5 PPT - Test organisms (species):
- other: Salmo gairdnerii
- Details on test organisms:
- - LIFE STAGE:Fingerling
- Length at study initiation (length definition, mean, range and SD): <= 4 in - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Test temperature:
- 12.77 deg.C
- pH:
- 7.5 to 8.2
- Dissolved oxygen:
- 8.6 to 13.7 ppm
- Details on test conditions:
- No data
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In short term fish toxicity study, no effects were observed for 1H-benzimidazole at dose concentration 5 mg/l on fish species Salmo gairdreii thus, the NOEC value is 5 mg/l for 24 hrs exposure period.
- Executive summary:
Short term toxicity study on fish species Salmo gairdreii, Lepomis macrochirus and Petromyzon marinus was carried out for 24 hrs. Test was performed under static condition and fresh water medium (lake water) and pH maintained as 7.5 to 8.2, test temperature 12.77 deg.C and dissolved oxygen as 8.6 to 13.7 ppm. No effects were observed at dose concentration 5 mg/l on the test fish species Salmo gairdreii, Lepomis macrochirus and Petromyzon marinus thus the NOEC value for test chemical was consider to be 5 mg/l for 24 hrs exposure period.
Reference
Description of key information
Short term toxicity study on fish species Salmo gairdreii, Lepomis macrochirus and Petromyzon marinus was carried out for 24 hrs. Test was performed under static condition and fresh water medium (lake water) and pH maintained as 7.5 to 8.2, test temperature 12.77 deg.C and dissolved oxygen as 8.6 to 13.7 ppm. No effects were observed at dose concentration 5 mg/l on the test fish species Salmo gairdreii, Lepomis macrochirus and Petromyzon marinus thus the NOEC value for test chemical was consider to be 5 mg/l for 24 hrs exposure period.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Based on the experimental data from various database for the target chemical study have been reviewed to determine the mode of action of Benzimidazole (CAS No. 51 -17 -2) on the mortality rate and behavior of fish. The studies are as mentioned below:
In the first key study from handbook or collection of data, short term toxicity study on fish species Salmo gairdreii, Lepomis macrochirus and Petromyzon marinus was carried out for 24 hrs. Test was performed under static condition and fresh water medium (lake water) and pH maintained as 7.5 to 8.2, test temperature 12.77 deg.C and dissolved oxygen as 8.6 to 13.7 ppm. No effects were observed at dose concentration 5 mg/l on the test fish species Salmo gairdreii, Lepomis macrochirus and Petromyzon marinus thus the NOEC value for test chemical was consider to be 5 mg/l for 24 hrs exposure period.
First study was supported by another experimental studies. Short term toxicity study on fish species Petromyzon marinus was carried out for 24 hrs. Test was performed under static condition and fresh water medium (lake water) and pH maintained as 7.5 to 8.2, test temperature 12.77 deg.C and dissolved oxygen as 8.6 to 13.7 ppm. No effects were observed at dose concentration 5 mg/l on the test fish species Salmo gairdreii, Lepomis macrochirus and Petromyzon marinus thus for test chemical, the NOEC value was consider to be 5 mg/l for 24 hrs exposure period.
Similarly another study was designed to access the toxic effects of the test compound on the Zebra fish (Danio rerio). Test was conducted in compliance with the OECD guideline 203. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 1 g of the test substance in 4 liters of potable water (passed through reverse osmosis system) with continuous stirring for achieving test concentrations of 100 mg/L, respectively. Test conducted at limit test concentration 100 mg/l and Zebra fishes were exposed to this concentration for 96 hours. Test animal was collected from Orange City Aquarium, Sitabuldi, Nagpur, MS (India). 8 fishes exposed to the test concentration. Aeration in test vessels was provided 1 day before the start of experiment. After the exposure of chemical (mortality, visible symptoms, pH, Temperature, dissolved oxygen content) were recorded after 24 hours, 48 hours, 72 hours and 96 hours of the start of the experiment. Based on nominal concentrations, experimental median lethal Concentrations [LC-50 (96 h)] for test chemical on Zebra fish (Danio rerio) was determined to be > 100 mg/L by observing the mortality. Thus based on LC50 it can be concluded that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.
Thus on the basis of overall studies chemicalBenzimidazole (CAS No. 51 -17 -2)was consider as nontoxic to fishes and not classified as per the CLP classification criteria.
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