Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Bioaccumulation: aquatic / sediment:

Based on an experimental log/octanol water partition coefficient of 1.32, a bioconcentration factor of 2.1 (dimensionless)can be calculated for  1H-benzimidazole (i.e benzimidazol) using an regression derived equation. This BCF suggests the potential of target chemical (CAS no.51 -17 -2) for bioconcentration in aquatic organisms is low.

Additional information

Bioaccumulation: aquatic / sediment:

Four different studies which includes one experimental from authorative database and remaining three from validated predicted databases for bioaccumulation endpoint of target chemical 1H-benzimidazole (CAS no. 51-17-2) are summarized as followed:

 

First study from experimental result from authoritative database (HSDB by US EPA; 2017) suggest the bio concentration factor (BCF) for 1H-benzimidazole is 2.1 (dimensionless) based on an experimental log/octanol water partition coefficient of 1.32 and using an regression derived equation. This BCF indicate the potential of target chemical (CAS no.51 -17 -2) for bioconcentration in aquatic organisms is low.

Above experimental result is supported by prediction report by BCFBAF (v3.00) model which indicate the estimated bio concentration factor (BCF) for 1H-benzimidazole is 3.451 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that 1H-benzimidazole is not expected to bio accumulate in the food chain.

Another predicted database, PBT profiler propose the Bioaccumulation factor (BCF) was predicted to be 3.4 L/kg wet-wt at 25 deg.C for test chemical 1H-benzimidazole.

And Scifinder database indicate the Bioconcentration factor (BCF) for target chemical 1H-benzimidazole was predicted to be 1.0 at pH 1-4; 1.29 at pH 5; 4.35 at pH 6; 5.72 at pH 7; 5.91 at pH 8;5.93 at pH 9 and 5.92 at pH 10 and temperature 25 deg.C. Based on the BCF concentration at all pH range i.e 1 -10 it is concluded that the test chemical 1H-benzimidazole is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

 

All predicted and experimental values for bioaccumulation is in the range of 1.0 -5.93 (L/kg or dimensionless) conclude the target chemical 1H-benzimidazole (CAS no. 51-17-2) is non bioaccumulative in aquatic environment as it does not exceed the BCF criteria of 2000.