Registration Dossier
Registration Dossier
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EC number: 464-700-1 | CAS number: 607724-42-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The EC50 for the test substance was found to be >10000 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 10 000 mg/L
Additional information
A study was conducted to evaluate the toxicity of the test substance to bacteria according to EU Method C.11 (equivalent to OECD Guideline 209), in compliance with GLP. The activated sludge (predominantly from a domestic source) was exposed to substance at 100, 1000 and 10,000 mg/L. The respiration rate of each mixture was determined after aeration periods of 3 h. The inhibitory effect at a particular concentration was expressed as a percentage of the mean of the respiration rates of two controls. An EC50 value was calculated from the respiration rates at different concentrations. A reference substance, 3, 5-dichlorophenol, was used at 5, 10 and 20 mg/L. The test substance showed 3.0% respiration inhibition of activated sludge at 10,000 mg/L and no physicochemical oxygen consumption was observed at this test concentration. Under the test conditions, the EC50 for the test substance was found to be >10,000 mg/L (Bruns, 2005d).
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