Registration Dossier
Registration Dossier
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EC number: 464-700-1 | CAS number: 607724-42-5
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The half-life of the test substance under environmental conditions (25°C) was estimated to be >1 year at pH 4 and <1 d at pH 7 and 9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 24 h
- at the temperature of:
- 25 °C
Additional information
A study was conducted to determine hydrolysis as a function of pH for the test substance according to OECD Guideline 111 and EU Method C.7, in compliance with GLP.
The study comprised of the pre-tests at 50°C with buffers at pH 4, 7 and 9. The decomposition at pH 4 was below 10% after 5 d at 50°C. Thus the test substance was considered hydrolytically stable at pH 4. According to the guideline a half-life period of more than one year under environmental conditions (25°C) was estimated and no additional testing was required. The decomposition at pH 7 and pH 9 was higher than 50% after 2.4 h at 50°C. Thus the test substance was considered hydrolytically unstable at pH 7 and pH 9. According to the guideline a half-life period of lower than 1 d under environmental conditions (25°C) was estimated and no additional testing was required.
Recoveries of the 'Recheck samples' ranged between 96.9% and 102.7%, indicating a good accuracy of the analytical method.
Under the test conditions, the half-life of the test substance under environmental conditions (25°C) was estimated to be >1 year at pH 4 and <1 d at pH 7 and 9.
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