Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-615-4 | CAS number: 108-78-1
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Estimation and software used by the US EPA.
Data source
Referenceopen allclose all
- Reference Type:
- other: QSAR
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The permeation coefficient is estimated from the partition coefficient n-octanol/water and the molecular mass.
- GLP compliance:
- no
Test material
- Reference substance name:
- Melamine
- EC Number:
- 203-615-4
- EC Name:
- Melamine
- Cas Number:
- 108-78-1
- Molecular formula:
- C3H6N6
- IUPAC Name:
- 1,3,5-triazine-2,4,6-triamine
- Details on test material:
- Melamine.
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: none.
Administration / exposure
- Details on in vitro test system (if applicable):
- The skin permeation coefficient Kp was estimated by the equation:
log Kp = -2.72 + 0.71 log Kow - 0.0061 MW.
The log Kow = -1.22 of Section 4.7 was entered in the calculation. MW = 126.12.
Results and discussion
Any other information on results incl. tables
Kp = 4.41*10-5 cm/h.
For a concentration of melamine in water of 3.5 g/L (saturation) and an event duration of 0.25 h the skin permeation coefficient corresponds to calculated dermal absorbed doses DA for 2 models applied:
DA = 3.9*10-5 mg/cm2
DA = 1.5*10-4 mg/cm2
Applicant's summary and conclusion
- Executive summary:
A skin permeation coefficient Kp = 4.41*10-5 cm/h was estimated for melamine.
High penetration is considered likely in case Kp exceeds 10-2 cm/h, and low penetration is expected in case Kp is lower than 10-5 cm/h.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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