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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-471-2 | CAS number: 107-19-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.7 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: MAK value derivation (OEL)
- Overall assessment factor (AF):
- 2.5
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 11.6 mg/m³
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 9.4 mg/m³
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 9.4 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- Overall assessment factor (AF):
- 6
- Dose descriptor starting point:
- NOAEC
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.83 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 24
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 20 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- not necessary, since the exposure route of the original study was the dermal application
- AF for dose response relationship:
- 1
- Justification:
- default value
- AF for differences in duration of exposure:
- 2
- Justification:
- default value for time extrapolation from subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 2.4
- Justification:
- default value for correction of differences in metabolic rate (rabbit to human)
- AF for intraspecies differences:
- 5
- Justification:
- default value (worker)
- AF for the quality of the whole database:
- 1
- Justification:
- guideline study
- AF for remaining uncertainties:
- 1
- Justification:
- toxicodynamic differences between humans and rabbits are not assumed; therefore, the assessment factor for remaining differences is set to 1
Acute/short term exposure
- Hazard assessment conclusion:
- no DNEL required: short term exposure controlled by conditions for long-term
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
Long-term exposure - local effects
inhalation
Local toxicity was seen in several inhalation toxicity studies in the nasal cavity of rats and mice, mainly in the form of histopathological changes on the respiratory and olfactory epithelium. Subacute, subchronic and chronic studies in mice and rats were performed. The LOAEC and NOAEC values obtained in these studies for effects in the nasal cavity are shown in the following table:
Study duration |
Species |
LOAEC [ppm] |
NOAEC [ppm] |
Reference |
||
female |
male |
female |
male |
|||
14 -d |
mouse |
n.e. |
88 |
n.e. |
25 |
Zissu, 1995 |
|
rat |
50 |
50 |
10 |
10 |
BASF, 1990 |
90 -d |
mouse |
16 |
16 |
8 |
8 |
NIH, 2008 |
|
rat |
8 |
16 |
4 |
8 |
NIH, 2008 |
2 -y |
mouse |
8 |
8 |
<8 |
<8 |
NIH, 2008 |
|
rat |
16 |
16 |
<16 |
<16 |
NIH, 2008 |
The data show that mice and rats are of comparable sensitivity regarding local effects in the nose. In the chronic toxicity study a NOAEC could not be established because histopathological changes in the nasal cavity were still found at the lowest exposure concentration of 8 ppm and 16 ppm in mouse and rat, respectively. Applying a LOAEC to NOAEC assessment factor of 3 to the lowest chronic LOAEC of 8 ppm leads to a calculated NOAEC of 2.7 ppm. This chronic NOAEC is in very good agreement with the chronic NOAEC of 2.0 - 2.7 ppm which arises from the extrapolation of the lowest subchronic NOAEC of 4 ppm to the chronic situation using a time extrapolation factor in the range of 1.5 to 2. The chronic NOAEC of 2.0 - 2.7 ppm is two-fold lower than the corresponding NOAEC of 5 ppm derived for systemic effects (see above). The NOAEC of 2.0 - 2.7 ppm is based on local toxic effects in the rodent nose. Due to the higher respiration frequency and volume/kg bw rodents are more susceptible for the kind of observed lesions than humans. Therefore, the application of an additional assessment factor to the NOAEC for the derivation of a local long-term exposure DNEL is not needed. Thus, a local DNEL (long term inhalation exposure) of 2 ppm (or 4.7 mg/m³) can be derived from the available data, confirming the German OEL (= MAK value) of 2 ppm. Therefore, the DNEL for systemic effects after long term exposure is considered to ensure a sufficient level of protection for the local effects following long term inhalative exposure.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Additional information - General Population
Currently, a consumer use of propargyl alcohol is not foreseen. Since no consumer use is planned, a derivation of the DNELs for general population does not affect risk characterization at all.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.