Registration Dossier
Registration Dossier
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EC number: 215-684-8 | CAS number: 1344-00-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific asnd national standards, limited documentation, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- 24-exposure, abraded and intact skin
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Silicic acid, aluminum sodium salt
- EC Number:
- 215-684-8
- EC Name:
- Silicic acid, aluminum sodium salt
- Cas Number:
- 1344-00-9
- Molecular formula:
- nSiO2*mAl2O3*zNa2O n = 2-4; m = 0.12-3.20; z = 0.11-4.5
- IUPAC Name:
- aluminium(3+) sodium bis(oxosilanebis(olate))
- Test material form:
- solid: nanoform, no surface treatment
- Remarks:
- crystalline-free
Constituent 1
- Specific details on test material used for the study:
- Zeolex 23A
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Vehicle:
- water
- Duration of exposure:
- 24 h
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights
Results and discussion
Effect levelsopen allclose all
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Dose descriptor:
- LD0
- Effect level:
- >= 5 000 mg/kg bw
- Mortality:
- none: 0/16 (0/4 per each dose group)
- Clinical signs:
- other: no data
- Gross pathology:
- No pathological findings
- Other findings:
- Dermal reactions were limited to slight erythema and edema.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
