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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
secondary source
Title:
No information
Author:
Dillingham E.O. et al.
Year:
1973
Bibliographic source:
J. Pharmaceut. Sci., 62, 22-30, (1973); cited in BG Chemie (ed.): 2-Methylpropanol-1, in:|Toxicological Evaluations 1 - Potential Health Hazards of Existing Chemicals, Springer Verlag, Berlin, pp. 43-57, (1990)

Materials and methods

Principles of method if other than guideline:
The test substance was applied i.p. to mice to determine the LC50.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylpropan-1-ol
EC Number:
201-148-0
EC Name:
2-methylpropan-1-ol
Cas Number:
78-83-1
Molecular formula:
C4H10O
IUPAC Name:
2-methylpropan-1-ol
Specific details on test material used for the study:
Isobutanol

Test animals

Species:
mouse
Strain:
ICR
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Doses:
no data
No. of animals per sex per dose:
no data
Details on study design:
- Duration of observation period following administration: 7 days

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
312 mg/kg bw

Applicant's summary and conclusion