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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Seven Day Skin Irritation study in Rabbits
Author:
Eastman Kodak co.
Year:
1986
Bibliographic source:
TSCATS: OTS 0510692; cited in OECD SIDS "Isobutanol", Final September 2004
Reference Type:
secondary source
Title:
Unnamed
Year:
1986

Materials and methods

Principles of method if other than guideline:
Rabbits were exposed to isobutanol for 7 d to determine the skin irritation potential after repeated dermal exposition.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylpropan-1-ol
EC Number:
201-148-0
EC Name:
2-methylpropan-1-ol
Cas Number:
78-83-1
Molecular formula:
C4H10O
IUPAC Name:
2-methylpropan-1-ol
Specific details on test material used for the study:
Isobutanol

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Duration of treatment / exposure:
24 h per application
Frequency of treatment:
4-6 x 24 hr
Doses / concentrations
Dose / conc.:
0.3 other: mL undiluted test compound
No. of animals per sex per dose:
no data
Control animals:
no
Details on study design:
Post-exposure period: 72 hr

Results and discussion

Effect levels

Key result
Dose descriptor:
other: local toxicity
Basis for effect level:
other: highly irritant after repeated exposure under occlusive conditions; no systemic toxicity reported
Remarks on result:
not measured/tested

Any other information on results incl. tables

Four to 6 times repeated 24-hr occlusive exposure to 0.3 ml isobutanol caused severe edema and erythema with eschar formation, which persisted throughout the 72-hr post-observation period. Isobutanol was therefore judged to be "highly irritant”.

Applicant's summary and conclusion