Registration Dossier
Registration Dossier
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EC number: 201-148-0 | CAS number: 78-83-1
Specific investigations: other studies
Administrative data
- Endpoint:
- hepatotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Siegers C.P. et al.
- Year:
- 1 974
- Bibliographic source:
- Pharmacology, 12, 296-302, (1974); cited in BG Chemie (ed.): 2-Methylpropanol-1, in: Toxikologische Bewertung Nr.96, Ausgabe 01/97, BG Chemie,|Heidelberg, pp. 3-40, (1997)
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Siegers C.P. et al.
- Year:
- 1 974
- Bibliographic source:
- Pharmacology, 12, 296-302, (1974); cited in WHO: Environmental Health Criteria 65, WHO, Geneva,pp. 93 ff., (1987)
Materials and methods
- Principles of method if other than guideline:
- Hepatotoxicity and effects on liver enzymes were studied after single oral application in guinea pigs.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 2-methylpropan-1-ol
- EC Number:
- 201-148-0
- EC Name:
- 2-methylpropan-1-ol
- Cas Number:
- 78-83-1
- Molecular formula:
- C4H10O
- IUPAC Name:
- 2-methylpropan-1-ol
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- single
Doses / concentrationsopen allclose all
- Dose / conc.:
- 33.5 mg/kg bw (total dose)
- Dose / conc.:
- 335 mg/kg bw (total dose)
Results and discussion
- Details on results:
- No hepatotoxic effects were found 16 hrs after single oral application of 33.5 or 335 mg/kg isobutanol to Pirbright-White guinea pigs. No difference in the enzyme activities of serum SGOT, SGPT, and GLDH and in the triglyceride concentration were detected compared to a olive oil control group.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
